Structurally diverse diterpenoids from Isodon ternifolius collected from three regions

doi:10.1016/j.tet.2019.03.056

	Structurally diverse diterpenoids from Isodon ternifolius collected from three regions
	Gou, Lei-Lei 1,2; Hu, Kun1 ; Yang, Qian 1; Li, Xiao-Nian 1; Sun, Han-Dong1 ; Xiang, Chun-Lei3 ; Puno, Pema-Tenzin1
通讯作者	Xiang, Chun-Lei(xiangchunlei@mail.kib.ac.cn) ; Puno, Pema-Tenzin(punopematenzin@mail.kib.ac.cn)
	2019-05-10
发表期刊	TETRAHEDRON
ISSN	0040-4020
卷号	75 期号:19 页码:2797-2806
摘要	Phytochemical investigation of the aerial parts of Isodon ternifolius from three regions in Yunnan Province afforded 9 new diterpenoids, ternifoliusins A-1 (1-9), together with 26 known diterpenoids. Among them, ternifoliusins A-D possess rare 6,7:8,15-diseco-7,20-olide-6,8-cyclo-ent-kaurane diterpenoid scaffold. The structures of all compounds were determined by comprehensive spectroscopic analysis, as well as quantum chemical calculation methods. Moreover, the molecular constitutions and configurations of ternifoliusins A, E, and F (I, 5, 6) were confirmed by single-crystal X-ray diffraction analysis. Ten compounds were assayed for their cytotoxic activity against the HL-60, SMMC-7721, A-549, MCF-7, and SW-480 human tumor cell lines, and compounds 13, 17, 19, 20, 31 and 34 were demonstrated to be active against all of the five human tumor cell lines. (C) 2019 Elsevier Ltd. All rights reserved.
关键词	Isodon ternifolius Diterpenoids Cytotoxic activity NMR computation ECD calculation
DOI	10.1016/j.tet.2019.03.056
收录类别	SCI
语种	英语
WOS记录号	WOS:000467510100006
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/66909
专题	中国科学院东亚植物多样性与生物地理学重点实验室
通讯作者	Xiang, Chun-Lei; Puno, Pema-Tenzin
作者单位	1.Chinese Acad Sci, Yunnan Key Lab Nat Med Chem, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Chinese Acad Sci, Kunming Inst Bot, CAS Key Lab Plant Div & Biogeog East Asia, Kunming 650201, Yunnan, Peoples R China
推荐引用方式 GB/T 7714	Gou, Lei-Lei,Hu, Kun,Yang, Qian,et al. Structurally diverse diterpenoids from Isodon ternifolius collected from three regions[J]. TETRAHEDRON,2019,75(19):2797-2806.
APA	Gou, Lei-Lei.,Hu, Kun.,Yang, Qian.,Li, Xiao-Nian.,Sun, Han-Dong.,...&Puno, Pema-Tenzin.(2019).Structurally diverse diterpenoids from Isodon ternifolius collected from three regions.TETRAHEDRON,75(19),2797-2806.
MLA	Gou, Lei-Lei,et al."Structurally diverse diterpenoids from Isodon ternifolius collected from three regions".TETRAHEDRON 75.19(2019):2797-2806.

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