Structurally diverse diterpenoids from Isodon ternifolius collected from three regions
Gou, Lei-Lei1,2; Hu, Kun1; Yang, Qian1; Li, Xiao-Nian1; Sun, Han-Dong1; Xiang, Chun-Lei3; Puno, Pema-Tenzin1
Corresponding AuthorXiang, Chun-Lei(xiangchunlei@mail.kib.ac.cn) ; Puno, Pema-Tenzin(punopematenzin@mail.kib.ac.cn)
2019-05-10
Source PublicationTETRAHEDRON
ISSN0040-4020
Volume75Issue:19Pages:2797-2806
AbstractPhytochemical investigation of the aerial parts of Isodon ternifolius from three regions in Yunnan Province afforded 9 new diterpenoids, ternifoliusins A-1 (1-9), together with 26 known diterpenoids. Among them, ternifoliusins A-D possess rare 6,7:8,15-diseco-7,20-olide-6,8-cyclo-ent-kaurane diterpenoid scaffold. The structures of all compounds were determined by comprehensive spectroscopic analysis, as well as quantum chemical calculation methods. Moreover, the molecular constitutions and configurations of ternifoliusins A, E, and F (I, 5, 6) were confirmed by single-crystal X-ray diffraction analysis. Ten compounds were assayed for their cytotoxic activity against the HL-60, SMMC-7721, A-549, MCF-7, and SW-480 human tumor cell lines, and compounds 13, 17, 19, 20, 31 and 34 were demonstrated to be active against all of the five human tumor cell lines. (C) 2019 Elsevier Ltd. All rights reserved.
KeywordIsodon ternifolius Diterpenoids Cytotoxic activity NMR computation ECD calculation
DOI10.1016/j.tet.2019.03.056
Indexed BySCI
Language英语
WOS Research AreaChemistry
WOS SubjectChemistry, Organic
WOS IDWOS:000467510100006
Citation statistics
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/66909
Collection中国科学院东亚植物多样性与生物地理学重点实验室
Corresponding AuthorXiang, Chun-Lei; Puno, Pema-Tenzin
Affiliation1.Chinese Acad Sci, Yunnan Key Lab Nat Med Chem, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.Chinese Acad Sci, Kunming Inst Bot, CAS Key Lab Plant Div & Biogeog East Asia, Kunming 650201, Yunnan, Peoples R China
Recommended Citation
GB/T 7714
Gou, Lei-Lei,Hu, Kun,Yang, Qian,et al. Structurally diverse diterpenoids from Isodon ternifolius collected from three regions[J]. TETRAHEDRON,2019,75(19):2797-2806.
APA Gou, Lei-Lei.,Hu, Kun.,Yang, Qian.,Li, Xiao-Nian.,Sun, Han-Dong.,...&Puno, Pema-Tenzin.(2019).Structurally diverse diterpenoids from Isodon ternifolius collected from three regions.TETRAHEDRON,75(19),2797-2806.
MLA Gou, Lei-Lei,et al."Structurally diverse diterpenoids from Isodon ternifolius collected from three regions".TETRAHEDRON 75.19(2019):2797-2806.
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