| Structurally diverse diterpenoids from Isodon ternifolius collected from three regions | |
Gou, Lei-Lei1,2; Hu, Kun1 ; Yang, Qian1; Li, Xiao-Nian1; Sun, Han-Dong1; Xiang, Chun-Lei3; Puno, Pema-Tenzin1
| |
| Corresponding Author | Xiang, Chun-Lei(xiangchunlei@mail.kib.ac.cn) ; Puno, Pema-Tenzin(punopematenzin@mail.kib.ac.cn) |
| 2019-05-10 | |
| Source Publication | TETRAHEDRON
 |
| ISSN | 0040-4020 |
| Volume | 75Issue:19Pages:2797-2806 |
| Abstract | Phytochemical investigation of the aerial parts of Isodon ternifolius from three regions in Yunnan Province afforded 9 new diterpenoids, ternifoliusins A-1 (1-9), together with 26 known diterpenoids. Among them, ternifoliusins A-D possess rare 6,7:8,15-diseco-7,20-olide-6,8-cyclo-ent-kaurane diterpenoid scaffold. The structures of all compounds were determined by comprehensive spectroscopic analysis, as well as quantum chemical calculation methods. Moreover, the molecular constitutions and configurations of ternifoliusins A, E, and F (I, 5, 6) were confirmed by single-crystal X-ray diffraction analysis. Ten compounds were assayed for their cytotoxic activity against the HL-60, SMMC-7721, A-549, MCF-7, and SW-480 human tumor cell lines, and compounds 13, 17, 19, 20, 31 and 34 were demonstrated to be active against all of the five human tumor cell lines. (C) 2019 Elsevier Ltd. All rights reserved. |
| Keyword | Isodon ternifolius Diterpenoids Cytotoxic activity NMR computation ECD calculation |
| DOI | 10.1016/j.tet.2019.03.056 |
| Indexed By | SCI |
| Language | 英语 |
| WOS ID | WOS:000467510100006 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.kib.ac.cn/handle/151853/66909 |
| Collection | 中国科学院东亚植物多样性与生物地理学重点实验室 |
| Corresponding Author | Xiang, Chun-Lei; Puno, Pema-Tenzin |
| Affiliation | 1.Chinese Acad Sci, Yunnan Key Lab Nat Med Chem, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Chinese Acad Sci, Kunming Inst Bot, CAS Key Lab Plant Div & Biogeog East Asia, Kunming 650201, Yunnan, Peoples R China |
| Recommended Citation GB/T 7714 | Gou, Lei-Lei,Hu, Kun,Yang, Qian,et al. Structurally diverse diterpenoids from Isodon ternifolius collected from three regions[J]. TETRAHEDRON,2019,75(19):2797-2806. |
| APA | Gou, Lei-Lei.,Hu, Kun.,Yang, Qian.,Li, Xiao-Nian.,Sun, Han-Dong.,...&Puno, Pema-Tenzin.(2019).Structurally diverse diterpenoids from Isodon ternifolius collected from three regions.TETRAHEDRON,75(19),2797-2806. |
| MLA | Gou, Lei-Lei,et al."Structurally diverse diterpenoids from Isodon ternifolius collected from three regions".TETRAHEDRON 75.19(2019):2797-2806. |
| Files in This Item: | Download All | |||||
| File Name/Size | DocType | Version | Access | License | ||
| Gou-2019-Structurall（1097KB） | 期刊论文 | 出版稿 | 开放获取 | CC BY-NC-SA | View Download | |
Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.
Edit Comment