Antifeedant and Antiviral Diterpenoids from the Fresh Roots of Euphorbia jolkinii.

	Antifeedant and Antiviral Diterpenoids from the Fresh Roots of Euphorbia jolkinii.
	Huang, Chun-Shuai; Luo, Shi-Hong; Li, Yao-Lan; Li, Chun-Huan; Hua, Juan; Liu, Yan; Jing, Shu-Xi; Wang, Ying; Yang, Min-Jie; Li, Sheng-Hong
	2014
发表期刊	Natural products and bioprospecting
ISSN	2192-2195
卷号	4 期号:2 页码:91-100
摘要	ABSTRACT: The perennial herbaceous plant Euphorbia jolkinii (Euphorbiaceae) is a noxious weed widely distributed in the grasslands of northwestern Yunnan and has greatly threatened the local biodiversity. Phytochemical investigation on the fresh roots of E. jolkinii afforded six new diterpenoids 1, 2, 4-6, and 8, together with fifteen known diterpenoids. Their structures were elucidated on the basis of 1D and 2D NMR and other spectroscopic methods. Casbane, lathyrane, abietane, and ent-kaurane diterpenoids were reported from this plant for the first time. Selected compounds were evaluated for their antifeedant and anti-RSV (respiratory syncytial virus) activities. Compound 2 and ingenol (3) exhibited moderate antifeedant activity against a generalist insect herbivore, Spodoptera exigua, with EC50 values of 17.88 and 17.71mug/cm(2) respectively. Compound 19 showed significant anti-RSV activity, with 50% inhibition (IC50) value of 10.0muM and selective index of 8.0. Compounds 1 and 2 were less active against RSV virus, both with IC50 value of 25muM, and with selective indices of 1.0 and 3.2 respectively. These findings provided new evidence for the biological functions and utilization of the diversified diterpenoid metabolites in the roots of this rich but harmful plant.
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/64924
专题	植物化学与西部植物资源持续利用国家重点实验室
推荐引用方式 GB/T 7714	Huang, Chun-Shuai,Luo, Shi-Hong,Li, Yao-Lan,et al. Antifeedant and Antiviral Diterpenoids from the Fresh Roots of Euphorbia jolkinii.[J]. Natural products and bioprospecting,2014,4(2):91-100.
APA	Huang, Chun-Shuai.,Luo, Shi-Hong.,Li, Yao-Lan.,Li, Chun-Huan.,Hua, Juan.,...&Li, Sheng-Hong.(2014).Antifeedant and Antiviral Diterpenoids from the Fresh Roots of Euphorbia jolkinii..Natural products and bioprospecting,4(2),91-100.
MLA	Huang, Chun-Shuai,et al."Antifeedant and Antiviral Diterpenoids from the Fresh Roots of Euphorbia jolkinii.".Natural products and bioprospecting 4.2(2014):91-100.