Highly Oxygenated Limonoids and Lignans from Phyllanthus flexuosus.

	Highly Oxygenated Limonoids and Lignans from Phyllanthus flexuosus.
	Zhao, Jian-Qiang; Wang, Yan-Ming; Zhu, Hong-Tao; Wang, Dong; Li, Sheng-Hong; Cheng, Rong-Rong; Yang, Chong-Ren; Wang, Yi-Fei; Xu, Min; Zhang, Ying-Jun
	2014
发表期刊	Natural products and bioprospecting
ISSN	2192-2195
卷号	4 期号:4 页码:233-42
摘要	ABSTRACT: Two new highly oxygenated limonoids, flexuosoids A (1) and B (2), and three new arylnaphthalene lignan glycosides, phyllanthusmins D-F (3-5), were isolated from the roots of Phyllanthus flexuosus, in addition to three known lignans, phyllanthusmin C, arabelline, and (+)-diasyringaresinol. Their structures were elucidated on the basis of detailed spectroscopic analysis and chemical methods. Compounds 1 and 2, two new decaoxygenated limonoids with a C-19/29 lactol bridge and heptaoxygenated substituents at C-1, C-2, C-3, C-7, C-11, C-17, and C-30, represent the second example of limonoids in the Euphorbiaceae family. Most of the isolates were tested for their antifeedant, anti-herpes simplex virus 1, and cytotoxic activities. The new limonoids 1 and 2 showed promising antifeedant activity against the beet army worm (Spodoptera exigua) with EC50 values of 25.1 and 17.3mug/cm(2), respectively. In addition, both of them displayed moderate cytotoxicity against the ECA109 human esophagus cancer cell line, along with the known lignan glycoside, phyllanthusmin C, with the IC50 values of 11.5 (1), 8.5 (2), and 7.8 (phyllanthusmin C) muM, respectively.GRAPHICAL ABSTRACT: Two new highly oxygenated limonoids, flexuosoids A (1) and B (2), and three new arylnaphthalene lignan glycosides, phyllanthusmins D-F (3-5), were isolated from the roots of Phyllanthus flexuosus, along with three known lignans. Flexuosoids A (1) and B (2) showed promising antifeedant activity against the beet army worm (Spodoptera exigua) with EC50 values of 25.1 and 17.3mug/cm(2), respectively. In addition, both of them and the known lignan glycoside, phyllanthusmin C, displayed moderate cytotoxicity against the ECA109 human esophagus cancer cell line, with the IC50 values of 11.5, 8.5, and 7.8muM, respectively.
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/64915
专题	植物化学与西部植物资源持续利用国家重点实验室
推荐引用方式 GB/T 7714	Zhao, Jian-Qiang,Wang, Yan-Ming,Zhu, Hong-Tao,et al. Highly Oxygenated Limonoids and Lignans from Phyllanthus flexuosus.[J]. Natural products and bioprospecting,2014,4(4):233-42.
APA	Zhao, Jian-Qiang.,Wang, Yan-Ming.,Zhu, Hong-Tao.,Wang, Dong.,Li, Sheng-Hong.,...&Zhang, Ying-Jun.(2014).Highly Oxygenated Limonoids and Lignans from Phyllanthus flexuosus..Natural products and bioprospecting,4(4),233-42.
MLA	Zhao, Jian-Qiang,et al."Highly Oxygenated Limonoids and Lignans from Phyllanthus flexuosus.".Natural products and bioprospecting 4.4(2014):233-42.