alpha-Pyrone Derivatives from a Streptomyces Strain Resensitize Tamoxifen Resistance in Breast Cancer Cells.

	alpha-Pyrone Derivatives from a Streptomyces Strain Resensitize Tamoxifen Resistance in Breast Cancer Cells.
	Yang, Rui-Min; Zhang, Xiu-Lei; Wang, Li; Huang, Jian-Ping; Yang, Jing; Yan, Yi-Jun; Luo, Jian-Ying; Wang, Xiang-Ting; Huang, Sheng-Xiong
	2017
发表期刊	Natural products and bioprospecting
ISSN	2192-2195
卷号	7 期号:4 页码:329-334
摘要	Tamoxifen resistance (TamR) is the underlying cause of treatment failure in many breast cancer patients receiving tamoxifen. In order to look for noncytotoxic natural products with the ability to reverse TamR, an extract from strain Streptomyces sp. KIB-H0495 was detected to be active. Subsequent large scale fermentation and isolation led to the isolation of four alpha-pyrone derivatives including two new compounds, violapyrones J (2) and K (3), and two known analogues, violapyrones B (1) and I (4). Further bioactivity assays indicated that only 1 and 3 exerted potent resensitization effects on MCF-7/TamR cells at a concentration of 1muM. Owing to the simple structures of 1 and 3, these two compounds might have potential for further investigation as novel tamoxifen resensitization agent in breast cancer chemotherapy.
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/64836
专题	植物化学与西部植物资源持续利用国家重点实验室
推荐引用方式 GB/T 7714	Yang, Rui-Min,Zhang, Xiu-Lei,Wang, Li,et al. alpha-Pyrone Derivatives from a Streptomyces Strain Resensitize Tamoxifen Resistance in Breast Cancer Cells.[J]. Natural products and bioprospecting,2017,7(4):329-334.
APA	Yang, Rui-Min.,Zhang, Xiu-Lei.,Wang, Li.,Huang, Jian-Ping.,Yang, Jing.,...&Huang, Sheng-Xiong.(2017).alpha-Pyrone Derivatives from a Streptomyces Strain Resensitize Tamoxifen Resistance in Breast Cancer Cells..Natural products and bioprospecting,7(4),329-334.
MLA	Yang, Rui-Min,et al."alpha-Pyrone Derivatives from a Streptomyces Strain Resensitize Tamoxifen Resistance in Breast Cancer Cells.".Natural products and bioprospecting 7.4(2017):329-334.