Lycodine-Type Lycopodium Alkaloids from the Whole Plants of Huperzia serrata.
Liu, Yu-Chen; Zhang, Zhi-Jun; Su, Jia; Peng, Li-Yan; Pan, Lu-Tai; Wu, Xing-De; Zhao, Qin-Shi
2017
Source PublicationNatural products and bioprospecting
ISSN2192-2195
Volume7Issue:5Pages:405-411
AbstractThree new lycodine-type Lycopodium alkaloids, namely 1-methyllycodine (1), 8alpha-hydroxy-15,16-dehydro-des-N-methyl-alpha-obscurine (2), N-methyl-16-hydroxyhuperzine B (3), and one new natural lycodine-type Lycopodium alkaloid, N-methylhuperzine A (4), along with 11 known analogues (5-15), were isolated from the whole plants of club moss Huperzia serrata. The structures of 1-4 were elucidated on the basis of NMR spectroscopic and mass spectrometry data. Among them, compound 1 was the first lycodine-type alkaloid possessing a methyl group at C-1. In addition, the structure of 5 was confirmed by the single-crystal X-ray crystallography data and its 13C NMR was reported for the first time in current study. Compounds 1-5 were tested their BACE1 inhibitory activity.
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/64830
Collection植物化学与西部植物资源持续利用国家重点实验室
Recommended Citation
GB/T 7714
Liu, Yu-Chen,Zhang, Zhi-Jun,Su, Jia,et al. Lycodine-Type Lycopodium Alkaloids from the Whole Plants of Huperzia serrata.[J]. Natural products and bioprospecting,2017,7(5):405-411.
APA Liu, Yu-Chen.,Zhang, Zhi-Jun.,Su, Jia.,Peng, Li-Yan.,Pan, Lu-Tai.,...&Zhao, Qin-Shi.(2017).Lycodine-Type Lycopodium Alkaloids from the Whole Plants of Huperzia serrata..Natural products and bioprospecting,7(5),405-411.
MLA Liu, Yu-Chen,et al."Lycodine-Type Lycopodium Alkaloids from the Whole Plants of Huperzia serrata.".Natural products and bioprospecting 7.5(2017):405-411.
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