Design, synthesis and structure-activity relationships of mangostin analogs as cytotoxic agents

KIB OpenIR

	Design, synthesis and structure-activity relationships of mangostin analogs as cytotoxic agents
	Chi, Xiao-Qian; Zi, Cheng-Ting; Li, Hong-Mei; Yang, Liu; Lv, Yong-Feng; Li, Jin-Yu; Hou, Bo; Ren, Fu-Cai; Hu, Jiang-Miao; Zhou, Jun
	2018
发表期刊	RSC ADVANCES
ISSN	2046-2069
卷号	8 期号:72 页码:41377-41388
摘要	In order to better understand the structure-activity relationship of mangostin, a series of xanthone derivatives based on -mangostin were designed and synthesized. All the compounds were evaluated for their cytotoxicity against a panel of five human cancer cell lines (HL-60, SMMC-7721, A-549, MCF-7 and SW480) using MTT assays. Most of them showed cytotoxicity and most of all, compounds 1a and 2h showed the highest cytotoxic potency by HL-60 cancer cell lines with IC50 values of 5.96 M and 6.90 M respectively; compound 3e showed the highest cytotoxic potency against SMMC-7221 cancer cell line with IC50 values of 3.98 M; compounds 2e and 2m showed lower cytotoxicity but higher selectivity than -mangostin against HL-60 and SMMC-7221 cancer cell lines respectively. Structure-activity relationship analysis indicates that the maintenance of the isopentene group at C-8 is essential for the cytotoxic activity.
收录类别	SCI
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/64752
专题	中国科学院昆明植物研究所
推荐引用方式 GB/T 7714	Chi, Xiao-Qian,Zi, Cheng-Ting,Li, Hong-Mei,et al. Design, synthesis and structure-activity relationships of mangostin analogs as cytotoxic agents[J]. RSC ADVANCES,2018,8(72):41377-41388.
APA	Chi, Xiao-Qian.,Zi, Cheng-Ting.,Li, Hong-Mei.,Yang, Liu.,Lv, Yong-Feng.,...&Zhou, Jun.(2018).Design, synthesis and structure-activity relationships of mangostin analogs as cytotoxic agents.RSC ADVANCES,8(72),41377-41388.
MLA	Chi, Xiao-Qian,et al."Design, synthesis and structure-activity relationships of mangostin analogs as cytotoxic agents".RSC ADVANCES 8.72(2018):41377-41388.