C-8 N-Ethyl-2-pyrrolidinone-Substituted Flavan-3-ols from the Leaves of Camellia sinensis var. pubilimba

doi:10.1021/acs.jafc.8b02066

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	C-8 N-Ethyl-2-pyrrolidinone-Substituted Flavan-3-ols from the Leaves of Camellia sinensis var. pubilimba
	Meng, Xiu-Hua; Zhu, Hong-Tao; Yan, Hui; Wang, Dong; Yang, Chong-Ren; Zhang, Ying-Jun
通讯作者	Zhang, Ying-Jun(zhangyj@mail.kib.ac.cn)
	2018
发表期刊	JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
ISSN	0021-8561
卷号	66 期号:27 页码:7150-7155
摘要	Camellia sinensis var. pubilimba, one variety of the genus Camellia sect. Thea (Theaceae), has been used for producing green tea mainly by the local people of its growing areas of Guangxi province, China. Forty compounds, including eight C-8 N-ethyl-2-pyrrolidinone-substituted flavan-3-ols (1-8) and their substituted unit N-ethyl-5-hydroxy-2-pyrrolidinone (9), four flavan-3-ol monomers (10-13) and one dimer (14), nine flavonoids (15-23), three hydrolyzable tannins (24-26), two lignans (27-28), 11 simple phenolics (29-39), and caffeine (40), were first isolated and identified from the leaves. Their structures were determined by detailed spectroscopic analysis and comparison with the literature data and authentic samples. Both 1 and 4 were obtained as a mixture of the N-ethyl-2-pyrrolidinone C-5 enantiomers (la and lb and 4a and 4b), respectively, while the resolution of another three pairs of enantiomers (2 and 3, 5 and 6, and 7 and 8) was achieved. Among them, lb is a new compound whose NMR data together with its enantiomer (la) were reported for the first time, while 2 and 3 are two new natural products. Most of the isolates exhibited significant antioxidant activities, stronger than ascorbic acid and trolox, while parts of the isolates, particularly C-8 N-ethyl-2-pyrrolidinone-substituted flavan-3-ols, showed obvious inhibitory effects on acetylcholinesterase (AChE). The results indicated that C. sinensis var. pubilimba is a valuable plant resource for tea production.
关键词	Camellia sinensis var. pubilimba green tea C-8 N-ethyl-2-pyrrolidinone substituted flavan-3-ols AChE inhibitory activity antioxidant
DOI	10.1021/acs.jafc.8b02066
收录类别	SCI
语种	英语
WOS记录号	WOS:000439008800021
引用统计	被引频次：33[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/64710
专题	中国科学院昆明植物研究所
推荐引用方式 GB/T 7714	Meng, Xiu-Hua,Zhu, Hong-Tao,Yan, Hui,et al. C-8 N-Ethyl-2-pyrrolidinone-Substituted Flavan-3-ols from the Leaves of Camellia sinensis var. pubilimba[J]. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,2018,66(27):7150-7155.
APA	Meng, Xiu-Hua,Zhu, Hong-Tao,Yan, Hui,Wang, Dong,Yang, Chong-Ren,&Zhang, Ying-Jun.(2018).C-8 N-Ethyl-2-pyrrolidinone-Substituted Flavan-3-ols from the Leaves of Camellia sinensis var. pubilimba.JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,66(27),7150-7155.
MLA	Meng, Xiu-Hua,et al."C-8 N-Ethyl-2-pyrrolidinone-Substituted Flavan-3-ols from the Leaves of Camellia sinensis var. pubilimba".JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 66.27(2018):7150-7155.