Cytochalasans from the Endophytic Fungus Xylaria cf. curta with Resistance Reversal Activity against Fluconazole-Resistant Candida albicans

	Cytochalasans from the Endophytic Fungus Xylaria cf. curta with Resistance Reversal Activity against Fluconazole-Resistant Candida albicans
	Wang, Wen-Xuan 1; Lei, Xinxiang 1; Ai, Hong-Lian 1; Bai, Xue 2; Li, Jing1 ; He, Juan 1; Li, Zheng-Hui 1; Zheng, Yong-Sheng 1; Feng, Tao 1; Liu, Ji-Kai 1
	2019-02-15
Source Publication	ORGANIC LETTERS
ISSN	1523-7060
Volume	21 Issue:4 Pages:1108-1111
Abstract	Curtachalasins C-E (1-3), which have an unprecedent bridged 6/6/6/6 ring system, were identified from the endophytic fungus Xylaria cf. curta. Residual dipolar coupling analyses associating with density functional theory calculations were utilized to determine the relative configuration of noncrystallizable compound 2. The absolute configurations of 1-3 were determined by X-ray diffraction and electronic circular dichroism calculations. Remarkably, curtachalasin C (1) showed significant resistance reversal activity against fluconazole-resistant Candida albicans.
Indexed By	SCI
Language	英语
Document Type	期刊论文
Identifier	http://ir.kib.ac.cn/handle/151853/64599
Collection	植物化学与西部植物资源持续利用国家重点实验室
Corresponding Author	Ai, Hong-Lian; Feng, Tao; Liu, Ji-Kai
Affiliation	1.South Cent Univ Nationalities, Sch Pharmaceut Sci, Wuhan 430074, Hubei, Peoples R China 2.Chinese Acad Sci, Kunming Inst Bot, Kunming 650204, Yunnan, Peoples R China
Recommended Citation GB/T 7714	Wang, Wen-Xuan,Lei, Xinxiang,Ai, Hong-Lian,et al. Cytochalasans from the Endophytic Fungus Xylaria cf. curta with Resistance Reversal Activity against Fluconazole-Resistant Candida albicans[J]. ORGANIC LETTERS,2019,21(4):1108-1111.
APA	Wang, Wen-Xuan.,Lei, Xinxiang.,Ai, Hong-Lian.,Bai, Xue.,Li, Jing.,...&Liu, Ji-Kai.(2019).Cytochalasans from the Endophytic Fungus Xylaria cf. curta with Resistance Reversal Activity against Fluconazole-Resistant Candida albicans.ORGANIC LETTERS,21(4),1108-1111.
MLA	Wang, Wen-Xuan,et al."Cytochalasans from the Endophytic Fungus Xylaria cf. curta with Resistance Reversal Activity against Fluconazole-Resistant Candida albicans".ORGANIC LETTERS 21.4(2019):1108-1111.

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