Cytochalasans from the Endophytic Fungus Xylaria cf. curta with Resistance Reversal Activity against Fluconazole-Resistant Candida albicans
Wang, Wen-Xuan1; Lei, Xinxiang1; Ai, Hong-Lian1; Bai, Xue2; Li, Jing1; He, Juan1; Li, Zheng-Hui1; Zheng, Yong-Sheng1; Feng, Tao1; Liu, Ji-Kai1
2019-02-15
Source PublicationORGANIC LETTERS
ISSN1523-7060
Volume21Issue:4Pages:1108-1111
AbstractCurtachalasins C-E (1-3), which have an unprecedent bridged 6/6/6/6 ring system, were identified from the endophytic fungus Xylaria cf. curta. Residual dipolar coupling analyses associating with density functional theory calculations were utilized to determine the relative configuration of noncrystallizable compound 2. The absolute configurations of 1-3 were determined by X-ray diffraction and electronic circular dichroism calculations. Remarkably, curtachalasin C (1) showed significant resistance reversal activity against fluconazole-resistant Candida albicans.
Indexed BySCI
Language英语
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/64599
Collection植物化学与西部植物资源持续利用国家重点实验室
Corresponding AuthorAi, Hong-Lian; Feng, Tao; Liu, Ji-Kai
Affiliation1.South Cent Univ Nationalities, Sch Pharmaceut Sci, Wuhan 430074, Hubei, Peoples R China
2.Chinese Acad Sci, Kunming Inst Bot, Kunming 650204, Yunnan, Peoples R China
Recommended Citation
GB/T 7714
Wang, Wen-Xuan,Lei, Xinxiang,Ai, Hong-Lian,et al. Cytochalasans from the Endophytic Fungus Xylaria cf. curta with Resistance Reversal Activity against Fluconazole-Resistant Candida albicans[J]. ORGANIC LETTERS,2019,21(4):1108-1111.
APA Wang, Wen-Xuan.,Lei, Xinxiang.,Ai, Hong-Lian.,Bai, Xue.,Li, Jing.,...&Liu, Ji-Kai.(2019).Cytochalasans from the Endophytic Fungus Xylaria cf. curta with Resistance Reversal Activity against Fluconazole-Resistant Candida albicans.ORGANIC LETTERS,21(4),1108-1111.
MLA Wang, Wen-Xuan,et al."Cytochalasans from the Endophytic Fungus Xylaria cf. curta with Resistance Reversal Activity against Fluconazole-Resistant Candida albicans".ORGANIC LETTERS 21.4(2019):1108-1111.
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