Diversified abietane family diterpenoids from the leaves of Leucosceptrurn canum and their cytotoxic activity
Guo, Kai1,2,3; Liu, Yan-Chun1,2; Liu, Yan1,2; Luo, Shi-Hong1,2; Li, Wen-Yuan1,2,3; Li, Xiao-Nian1,2; Li, Sheng-Hong1,2
2019
Source PublicationPHYTOCHEMISTRY
ISSN0031-9422
Volume157Pages:43-52
AbstractTwenty-four diterpenoids of abietane family, including thirteen undescribed compounds and eleven known ones, were isolated from the leaves of Leucosceptrurn canum. Their structures were elucidated by comprehensive spectroscopic analyses (including 1D and 2D-NMR and HRMS), and in the case of 15-hydroxy-abieta-8,11,13-trien-3-one by single-crystal X-ray diffraction. Their frameworks are highly diversified, involving normal abietane, 9,10-epoxy-9,10-seco-abietane, 18(4 -> 3)-abeo-abietane, 3,4-seco-18(4 -> 3)-abeo-abietane, and 16-norabietane. Selected compounds were evaluated for their cytotoxic activity against three human tumor cell lines, NCI-H1975, HepG2 and MCF-7. Among them, 3 beta-hydroxy-abieta-8,13-diene, 3 beta-hydroxy-abieta-8,11,13,15-tetraene, and 3 beta-hydroxy-9,10-epoxy-9,10-seco-abieta-8,11,13-triene exhibited moderate cytotoxicity against all three cell lines with IC50 values ranging from 8.11 to 50.73 mu M, while 3 alpha-hydroxy-abieta-8,11,13,15-tetraene, 3 beta-hydroxy-abieta-8,11,13,15-tetraen-7-one, and 15-hydroxy-18(4 -> 3)-abeo-abieta-3,8,11,13-tetraene were selectively active with IC50 values ranging from 28.80 to 71.29 mu M.
KeywordLeucosceptrum canum Lamiaceae Diterpenoids Abietane family Cytotoxic activity
Indexed BySCI
Language英语
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/64304
Collection植物化学与西部植物资源持续利用国家重点实验室
Corresponding AuthorLi, Sheng-Hong
Affiliation1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
2.Yunnan Key Lab Nat Med Chem, Kunming 650201, Yunnan, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
Recommended Citation
GB/T 7714
Guo, Kai,Liu, Yan-Chun,Liu, Yan,et al. Diversified abietane family diterpenoids from the leaves of Leucosceptrurn canum and their cytotoxic activity[J]. PHYTOCHEMISTRY,2019,157:43-52.
APA Guo, Kai.,Liu, Yan-Chun.,Liu, Yan.,Luo, Shi-Hong.,Li, Wen-Yuan.,...&Li, Sheng-Hong.(2019).Diversified abietane family diterpenoids from the leaves of Leucosceptrurn canum and their cytotoxic activity.PHYTOCHEMISTRY,157,43-52.
MLA Guo, Kai,et al."Diversified abietane family diterpenoids from the leaves of Leucosceptrurn canum and their cytotoxic activity".PHYTOCHEMISTRY 157(2019):43-52.
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