Diversified abietane family diterpenoids from the leaves of Leucosceptrurn canum and their cytotoxic activity

	Diversified abietane family diterpenoids from the leaves of Leucosceptrurn canum and their cytotoxic activity
	Guo, Kai 1,2,3; Liu, Yan-Chun1,2 ; Liu, Yan 1,2; Luo, Shi-Hong1,2 ; Li, Wen-Yuan 1,2,3; Li, Xiao-Nian 1,2; Li, Sheng-Hong1,2
	2019
发表期刊	PHYTOCHEMISTRY
ISSN	0031-9422
卷号	157 页码:43-52
摘要	Twenty-four diterpenoids of abietane family, including thirteen undescribed compounds and eleven known ones, were isolated from the leaves of Leucosceptrurn canum. Their structures were elucidated by comprehensive spectroscopic analyses (including 1D and 2D-NMR and HRMS), and in the case of 15-hydroxy-abieta-8,11,13-trien-3-one by single-crystal X-ray diffraction. Their frameworks are highly diversified, involving normal abietane, 9,10-epoxy-9,10-seco-abietane, 18(4 -> 3)-abeo-abietane, 3,4-seco-18(4 -> 3)-abeo-abietane, and 16-norabietane. Selected compounds were evaluated for their cytotoxic activity against three human tumor cell lines, NCI-H1975, HepG2 and MCF-7. Among them, 3 beta-hydroxy-abieta-8,13-diene, 3 beta-hydroxy-abieta-8,11,13,15-tetraene, and 3 beta-hydroxy-9,10-epoxy-9,10-seco-abieta-8,11,13-triene exhibited moderate cytotoxicity against all three cell lines with IC50 values ranging from 8.11 to 50.73 mu M, while 3 alpha-hydroxy-abieta-8,11,13,15-tetraene, 3 beta-hydroxy-abieta-8,11,13,15-tetraen-7-one, and 15-hydroxy-18(4 -> 3)-abeo-abieta-3,8,11,13-tetraene were selectively active with IC50 values ranging from 28.80 to 71.29 mu M.
关键词	Leucosceptrum canum Lamiaceae Diterpenoids Abietane family Cytotoxic activity
收录类别	SCI
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/64304
专题	植物化学与西部植物资源持续利用国家重点实验室
通讯作者	Li, Sheng-Hong
作者单位	1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 2.Yunnan Key Lab Nat Med Chem, Kunming 650201, Yunnan, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Guo, Kai,Liu, Yan-Chun,Liu, Yan,et al. Diversified abietane family diterpenoids from the leaves of Leucosceptrurn canum and their cytotoxic activity[J]. PHYTOCHEMISTRY,2019,157:43-52.
APA	Guo, Kai.,Liu, Yan-Chun.,Liu, Yan.,Luo, Shi-Hong.,Li, Wen-Yuan.,...&Li, Sheng-Hong.(2019).Diversified abietane family diterpenoids from the leaves of Leucosceptrurn canum and their cytotoxic activity.PHYTOCHEMISTRY,157,43-52.
MLA	Guo, Kai,et al."Diversified abietane family diterpenoids from the leaves of Leucosceptrurn canum and their cytotoxic activity".PHYTOCHEMISTRY 157(2019):43-52.

条目包含的文件		下载所有文件
文件名称/大小	文献类型	版本类型	开放类型	使用许可
Guo-2019-Diversified（3814KB）	期刊论文	出版稿	开放获取	CC BY-NC-SA	浏览下载