Albocycline-type Macrolides with Antibacterial Activities from Streptomyces sp. 4205
Gu, Cheng-Zhen1; Yuan, Sheng-Hao2; Lu, Jing1; Qiao, Yi-Jun3; Song, Yuan-Yuan2; Elzaki, Mohammed Esmail Abdalla2; Yang, Chong-Ren3; Zhang, Ying-Jun3; Zeng, Ren-Sen2
2019
Source PublicationCHEMISTRY & BIODIVERSITY
ISSN1612-1872
Volume16Issue:1Pages:7
AbstractThe actinomycete genus Streptomyces is characterized by producing bioactive secondary metabolites, including antibiotics. In this study, chemical and biological investigations were carried out on Streptomyces strain 4205 isolated from the paddy soil, leading to the identification and characterization of 10 albocycline-type macrolides, among which 4 compounds were new, namely albocyclines A-D (1-4). The structures of 1-10 were identified according to the 1D- and 2D-NMR spectroscopic data. Furthermore, compounds 1-10 were evaluated for antimicrobial activity. Compounds 5-7 displayed antimicrobial activities against Candidaalbicans ATCC 90028 with the same MIC value of 10.0 mg/mL and the IC50 values of 1.5, 1.0, and 1.0 mg/mL, respectively. Thus, the research on Streptomyces sp. is of vital significance for developing new antibiotic agents.
KeywordStreptomyces albocycline-type macrolides antibiotic Candida albicans antimicrobial activity biological activity
Indexed BySCI
Language英语
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/64266
Collection植物化学与西部植物资源持续利用国家重点实验室
Corresponding AuthorZhang, Ying-Jun; Zeng, Ren-Sen
Affiliation1.Fujian Agr & Forestry Univ, Coll Life Sci, Fuzhou 350002, Fujian, Peoples R China
2.Fujian Agr & Forestry Univ, Coll Crop Sci, Fuzhou 350002, Fujian, Peoples R China
3.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
Recommended Citation
GB/T 7714
Gu, Cheng-Zhen,Yuan, Sheng-Hao,Lu, Jing,et al. Albocycline-type Macrolides with Antibacterial Activities from Streptomyces sp. 4205[J]. CHEMISTRY & BIODIVERSITY,2019,16(1):7.
APA Gu, Cheng-Zhen.,Yuan, Sheng-Hao.,Lu, Jing.,Qiao, Yi-Jun.,Song, Yuan-Yuan.,...&Zeng, Ren-Sen.(2019).Albocycline-type Macrolides with Antibacterial Activities from Streptomyces sp. 4205.CHEMISTRY & BIODIVERSITY,16(1),7.
MLA Gu, Cheng-Zhen,et al."Albocycline-type Macrolides with Antibacterial Activities from Streptomyces sp. 4205".CHEMISTRY & BIODIVERSITY 16.1(2019):7.
Files in This Item: Download All
File Name/Size DocType Version Access License
gu2018.pdf(1937KB)期刊论文出版稿开放获取CC BY-NC-SAView Download
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Gu, Cheng-Zhen]'s Articles
[Yuan, Sheng-Hao]'s Articles
[Lu, Jing]'s Articles
Baidu academic
Similar articles in Baidu academic
[Gu, Cheng-Zhen]'s Articles
[Yuan, Sheng-Hao]'s Articles
[Lu, Jing]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Gu, Cheng-Zhen]'s Articles
[Yuan, Sheng-Hao]'s Articles
[Lu, Jing]'s Articles
Terms of Use
No data!
Social Bookmark/Share
File name: gu2018.pdf
Format: Adobe PDF
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.