| Albocycline-type Macrolides with Antibacterial Activities from Streptomyces sp. 4205 | |
Gu, Cheng-Zhen1; Yuan, Sheng-Hao2; Lu, Jing1; Qiao, Yi-Jun3; Song, Yuan-Yuan2; Elzaki, Mohammed Esmail Abdalla2; Yang, Chong-Ren3; Zhang, Ying-Jun3 ; Zeng, Ren-Sen2
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| 2019 | |
| 发表期刊 | CHEMISTRY & BIODIVERSITY
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| ISSN | 1612-1872 |
| 卷号 | 16期号:1页码:7 |
| 摘要 | The actinomycete genus Streptomyces is characterized by producing bioactive secondary metabolites, including antibiotics. In this study, chemical and biological investigations were carried out on Streptomyces strain 4205 isolated from the paddy soil, leading to the identification and characterization of 10 albocycline-type macrolides, among which 4 compounds were new, namely albocyclines A-D (1-4). The structures of 1-10 were identified according to the 1D- and 2D-NMR spectroscopic data. Furthermore, compounds 1-10 were evaluated for antimicrobial activity. Compounds 5-7 displayed antimicrobial activities against Candidaalbicans ATCC 90028 with the same MIC value of 10.0 mg/mL and the IC50 values of 1.5, 1.0, and 1.0 mg/mL, respectively. Thus, the research on Streptomyces sp. is of vital significance for developing new antibiotic agents. |
| 关键词 | Streptomyces albocycline-type macrolides antibiotic Candida albicans antimicrobial activity biological activity |
| 收录类别 | SCI |
| 语种 | 英语 |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kib.ac.cn/handle/151853/64266 |
| 专题 | 植物化学与西部植物资源持续利用国家重点实验室 |
| 通讯作者 | Zhang, Ying-Jun; Zeng, Ren-Sen |
| 作者单位 | 1.Fujian Agr & Forestry Univ, Coll Life Sci, Fuzhou 350002, Fujian, Peoples R China 2.Fujian Agr & Forestry Univ, Coll Crop Sci, Fuzhou 350002, Fujian, Peoples R China 3.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China |
| 推荐引用方式 GB/T 7714 | Gu, Cheng-Zhen,Yuan, Sheng-Hao,Lu, Jing,et al. Albocycline-type Macrolides with Antibacterial Activities from Streptomyces sp. 4205[J]. CHEMISTRY & BIODIVERSITY,2019,16(1):7. |
| APA | Gu, Cheng-Zhen.,Yuan, Sheng-Hao.,Lu, Jing.,Qiao, Yi-Jun.,Song, Yuan-Yuan.,...&Zeng, Ren-Sen.(2019).Albocycline-type Macrolides with Antibacterial Activities from Streptomyces sp. 4205.CHEMISTRY & BIODIVERSITY,16(1),7. |
| MLA | Gu, Cheng-Zhen,et al."Albocycline-type Macrolides with Antibacterial Activities from Streptomyces sp. 4205".CHEMISTRY & BIODIVERSITY 16.1(2019):7. |
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| gu2018.pdf（1937KB） | 期刊论文 | 出版稿 | 开放获取 | CC BY-NC-SA | 浏览 下载 | |
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