Emeridones A-F, a Series of 3,5-Demethylorsellinic Acid-Based Meroterpenoids with Rearranged Skeletons from an Endophytic Fungus Emericella sp. TJ29
Li, Qin1; Chen, Chunmei1; Cheng, Li1,3; Wei, Mengsha1; Dai, Chong1; He, Yan2; Gong, Jiaojiao1; Zhu, Runqi1; Li, Xiao-Nian4; Liu, Junjun1; Wang, Jianping1; Zhu, Hucheng1; Zhang, Yonghui1
2019-02-01
Source PublicationJOURNAL OF ORGANIC CHEMISTRY
ISSN0022-3263
Volume84Issue:3Pages:1534-1541
AbstractSix new 3,5-demethylorsellinic acid-based meroterpenoids, emeridones A-F (1-6), and eight known analogues (7-14) were isolated from Emericella sp. TJ29. Their structures and absolute configurations were elucidated by comprehensive spectroscopic analyses, single-crystal X-ray diffraction experiments, and electronic circular dichroism calculations. Emeridone A (1) represents the first meroterpenoid featuring a unique rigid 6/6/5/6 tetracyclic carbon ring system with two additional lactone rings. Emeridones B and C (2 and 3) possess a 2,6-dioxabicyclo[2.2.1]heptane and a spiro[bicyclo[3.2.2]nonane-2,1'-cyclohexane] moiety, respectively, and both functionalities were found for the second time in meroterpenoids. These new compounds were evaluated for their cytotoxic activities against five human cancer cells, and compounds 2, 4, and 6 exhibited moderate cytotoxic activities, with IC50 values ranging from 8.19 to 18.80 mu M.
Indexed BySCI
Language英语
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/64199
Collection植物化学与西部植物资源持续利用国家重点实验室
Corresponding AuthorZhu, Hucheng; Zhang, Yonghui
Affiliation1.Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Pharm, Hubei Key Lab Nat Med Chem & Resource Evaluat, Wuhan 430030, Hubei, Peoples R China
2.Huazhong Univ Sci & Technol, Tongji Med Coll, Tongji Hosp, Wuhan 430030, Hubei, Peoples R China
3.Hubei Univ Med, Coll Pharm, Shiyan 442000, Peoples R China
4.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
Recommended Citation
GB/T 7714
Li, Qin,Chen, Chunmei,Cheng, Li,et al. Emeridones A-F, a Series of 3,5-Demethylorsellinic Acid-Based Meroterpenoids with Rearranged Skeletons from an Endophytic Fungus Emericella sp. TJ29[J]. JOURNAL OF ORGANIC CHEMISTRY,2019,84(3):1534-1541.
APA Li, Qin.,Chen, Chunmei.,Cheng, Li.,Wei, Mengsha.,Dai, Chong.,...&Zhang, Yonghui.(2019).Emeridones A-F, a Series of 3,5-Demethylorsellinic Acid-Based Meroterpenoids with Rearranged Skeletons from an Endophytic Fungus Emericella sp. TJ29.JOURNAL OF ORGANIC CHEMISTRY,84(3),1534-1541.
MLA Li, Qin,et al."Emeridones A-F, a Series of 3,5-Demethylorsellinic Acid-Based Meroterpenoids with Rearranged Skeletons from an Endophytic Fungus Emericella sp. TJ29".JOURNAL OF ORGANIC CHEMISTRY 84.3(2019):1534-1541.
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