Irpeksins A-E, 1,10-seco-Eburicane-Type Triterpenoids from the Medicinal Fungus Irpex lacteus and Their Anti-NO Activity

	Irpeksins A-E, 1,10-seco-Eburicane-Type Triterpenoids from the Medicinal Fungus Irpex lacteus and Their Anti-NO Activity
	Tang, Yang 2,3; Zhao, Zhen-Zhu 2; Yao, Jian-Neng 2,3; Feng, Tao 1; Li, Zheng-Hui 1; Chen, He-Ping 1; Liu, Ji-Kai 1
	2018-10-01
发表期刊	JOURNAL OF NATURAL PRODUCTS
ISSN	0163-3864
卷号	81 期号:10 页码:2163-2168
摘要	Five new triterpenoids, irpeksins A E (1-5), were isolated from fruiting bodies of the medicinal fungus Irpex lacteus. The structures as well as absolute configurations of the new compounds were established via extensive spectroscopic analysis, computational methods, and Cotton effects. Compounds 1-4 are featured by a scaffold of 1,10-seco- and ring B aromatic eburicane (24-methyllanostane), and compound 5 is characterized by a scaffold of 1,10-9,11-diseco- and ring B aromatic eburicane, which represents unprecedented cleavage patterns in the lanostane family. Compounds 1-5 showed significant inhibitory activity against NO production in LPSactivated RAW 264.7 macrophage cells with IC50 values varying from 2.2 to 19.6 mu M.
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/63085
专题	植物化学与西部植物资源持续利用国家重点实验室
通讯作者	Chen, He-Ping; Liu, Ji-Kai
作者单位	1.South Cent Univ Nationalities, Sch Pharmaceut Sci, Wuhan 430074, Hubei, Peoples R China 2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Tang, Yang,Zhao, Zhen-Zhu,Yao, Jian-Neng,et al. Irpeksins A-E, 1,10-seco-Eburicane-Type Triterpenoids from the Medicinal Fungus Irpex lacteus and Their Anti-NO Activity[J]. JOURNAL OF NATURAL PRODUCTS,2018,81(10):2163-2168.
APA	Tang, Yang.,Zhao, Zhen-Zhu.,Yao, Jian-Neng.,Feng, Tao.,Li, Zheng-Hui.,...&Liu, Ji-Kai.(2018).Irpeksins A-E, 1,10-seco-Eburicane-Type Triterpenoids from the Medicinal Fungus Irpex lacteus and Their Anti-NO Activity.JOURNAL OF NATURAL PRODUCTS,81(10),2163-2168.
MLA	Tang, Yang,et al."Irpeksins A-E, 1,10-seco-Eburicane-Type Triterpenoids from the Medicinal Fungus Irpex lacteus and Their Anti-NO Activity".JOURNAL OF NATURAL PRODUCTS 81.10(2018):2163-2168.