Irpeksins A-E, 1,10-seco-Eburicane-Type Triterpenoids from the Medicinal Fungus Irpex lacteus and Their Anti-NO Activity
Tang, Yang2,3; Zhao, Zhen-Zhu2; Yao, Jian-Neng2,3; Feng, Tao1; Li, Zheng-Hui1; Chen, He-Ping1; Liu, Ji-Kai1
2018-10-01
Source PublicationJOURNAL OF NATURAL PRODUCTS
ISSN0163-3864
Volume81Issue:10Pages:2163-2168
AbstractFive new triterpenoids, irpeksins A E (1-5), were isolated from fruiting bodies of the medicinal fungus Irpex lacteus. The structures as well as absolute configurations of the new compounds were established via extensive spectroscopic analysis, computational methods, and Cotton effects. Compounds 1-4 are featured by a scaffold of 1,10-seco- and ring B aromatic eburicane (24-methyllanostane), and compound 5 is characterized by a scaffold of 1,10-9,11-diseco- and ring B aromatic eburicane, which represents unprecedented cleavage patterns in the lanostane family. Compounds 1-5 showed significant inhibitory activity against NO production in LPSactivated RAW 264.7 macrophage cells with IC50 values varying from 2.2 to 19.6 mu M.
Language英语
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/63085
Collection植物化学与西部植物资源持续利用国家重点实验室
Corresponding AuthorChen, He-Ping; Liu, Ji-Kai
Affiliation1.South Cent Univ Nationalities, Sch Pharmaceut Sci, Wuhan 430074, Hubei, Peoples R China
2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
Recommended Citation
GB/T 7714
Tang, Yang,Zhao, Zhen-Zhu,Yao, Jian-Neng,et al. Irpeksins A-E, 1,10-seco-Eburicane-Type Triterpenoids from the Medicinal Fungus Irpex lacteus and Their Anti-NO Activity[J]. JOURNAL OF NATURAL PRODUCTS,2018,81(10):2163-2168.
APA Tang, Yang.,Zhao, Zhen-Zhu.,Yao, Jian-Neng.,Feng, Tao.,Li, Zheng-Hui.,...&Liu, Ji-Kai.(2018).Irpeksins A-E, 1,10-seco-Eburicane-Type Triterpenoids from the Medicinal Fungus Irpex lacteus and Their Anti-NO Activity.JOURNAL OF NATURAL PRODUCTS,81(10),2163-2168.
MLA Tang, Yang,et al."Irpeksins A-E, 1,10-seco-Eburicane-Type Triterpenoids from the Medicinal Fungus Irpex lacteus and Their Anti-NO Activity".JOURNAL OF NATURAL PRODUCTS 81.10(2018):2163-2168.
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