Irpeksins A-E, 1,10-seco-Eburicane-Type Triterpenoids from the Medicinal Fungus Irpex lacteus and Their Anti-NO Activity
Tang, Yang2,3; Zhao, Zhen-Zhu2; Yao, Jian-Neng2,3; Feng, Tao1; Li, Zheng-Hui1; Chen, He-Ping1; Liu, Ji-Kai1
2018-10-01
发表期刊JOURNAL OF NATURAL PRODUCTS
ISSN0163-3864
卷号81期号:10页码:2163-2168
摘要Five new triterpenoids, irpeksins A E (1-5), were isolated from fruiting bodies of the medicinal fungus Irpex lacteus. The structures as well as absolute configurations of the new compounds were established via extensive spectroscopic analysis, computational methods, and Cotton effects. Compounds 1-4 are featured by a scaffold of 1,10-seco- and ring B aromatic eburicane (24-methyllanostane), and compound 5 is characterized by a scaffold of 1,10-9,11-diseco- and ring B aromatic eburicane, which represents unprecedented cleavage patterns in the lanostane family. Compounds 1-5 showed significant inhibitory activity against NO production in LPSactivated RAW 264.7 macrophage cells with IC50 values varying from 2.2 to 19.6 mu M.
资助信息National Natural Science Foundation of China; National Key Technologies R&D Program of China; Supercomputing Center of the Chinese Academy of Sciences in Beijing
语种英语
资助项目National Natural Science Foundation of China[81561148013] ; National Natural Science Foundation of China[81773590] ; National Key Technologies R&D Program of China[2017YFC1704007] ; Supercomputing Center of the Chinese Academy of Sciences in Beijing
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/63085
专题植物化学与西部植物资源持续利用国家重点实验室
通讯作者Chen, He-Ping; Liu, Ji-Kai
作者单位1.South Cent Univ Nationalities, Sch Pharmaceut Sci, Wuhan 430074, Hubei, Peoples R China
2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
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Tang, Yang,Zhao, Zhen-Zhu,Yao, Jian-Neng,et al. Irpeksins A-E, 1,10-seco-Eburicane-Type Triterpenoids from the Medicinal Fungus Irpex lacteus and Their Anti-NO Activity[J]. JOURNAL OF NATURAL PRODUCTS,2018,81(10):2163-2168.
APA Tang, Yang.,Zhao, Zhen-Zhu.,Yao, Jian-Neng.,Feng, Tao.,Li, Zheng-Hui.,...&Liu, Ji-Kai.(2018).Irpeksins A-E, 1,10-seco-Eburicane-Type Triterpenoids from the Medicinal Fungus Irpex lacteus and Their Anti-NO Activity.JOURNAL OF NATURAL PRODUCTS,81(10),2163-2168.
MLA Tang, Yang,et al."Irpeksins A-E, 1,10-seco-Eburicane-Type Triterpenoids from the Medicinal Fungus Irpex lacteus and Their Anti-NO Activity".JOURNAL OF NATURAL PRODUCTS 81.10(2018):2163-2168.
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