Metabolomic analysis of cholestatic liver damage in mice
Yang, Rui1,2; Zhao, Qi1,2; Hu, Dan-Dan1,3,4; Xiao, Xue-Rong1; Huang, Jian-Feng1,2; Li, Fei1
2018-10-01
发表期刊FOOD AND CHEMICAL TOXICOLOGY
ISSN0278-6915
卷号120页码:253-260
摘要Cholestasis is characterized by the obstruction of bile duct, including primary biliary cirrhosis (PBC) and primary sclerosing cholangitis (PSC). The complicated etiology and injury mechanism greatly limits the development of new drugs for its treatment. To better understand the mechanism of cholestatic liver damage, ultra-performance liquid chromatography-linked electrospray ionization quadrupole time-of-flight mass spectrometry (UPLC-ESI-QTOFMS) and multivariate data analysis were used to determine the metabolic changes in three recognized mouse cholestasis models. The cholestatic liver damage was generated by alphanaphthyl isothiocyanate (ANIT), 3,5-diethoxycarbonyl-1,4-dihydrocollidine (DDC) and lithocholic acid (LCA). The results indicated that the levels of bile acids were commonly increased in plasma of three mouse cholestasis models, while arginine was decreased. The level of plasma glutathione was decreased in ANIT- and LCA-induced intrahepatic PBC and PSC, respectively. But, the liver glutathione was decreased in DDC induced extrahepatic PSC. The level of plasma phospholipids was elevated in ANIT and DDC models, whereas that was depleted in LCA model. And protoporphyrin IX was significantly increased in the liver of DDC model. These metabolomics data could potentially distinguish the metabolic differences of three types of cholestasis, contributing to the understanding of the potential mechanism of cholestatic liver damage.
关键词Cholestatic liver damage PBC PSC Metabolomics QTOFMS
资助信息National Key Research and Development Program of China; CAS "Light of West China" Program; Kunming Institute of Botany; State Key Laboratory of Phytochemistry and Plant Resources in West China; Thousand Young Talents Program of China
语种英语
资助项目National Key Research and Development Program of China[2017YFC0906903] ; National Key Research and Development Program of China[2017YFC1700906] ; CAS "Light of West China" Program[Y72E8211W1] ; Kunming Institute of Botany[Y76E1211K1] ; Kunming Institute of Botany[Y4662211K1] ; State Key Laboratory of Phytochemistry and Plant Resources in West China[52Y67A9211Z1] ; Thousand Young Talents Program of China
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文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/62793
专题植物化学与西部植物资源持续利用国家重点实验室
通讯作者Li, Fei
作者单位1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.Kunming Med Univ, Sch Pharmaceut Sci, Kunming 650500, Yunnan, Peoples R China
4.Kunming Med Univ, Yunnan Key Lab Pharmacol Nat Prod, Kunming 650500, Yunnan, Peoples R China
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Yang, Rui,Zhao, Qi,Hu, Dan-Dan,et al. Metabolomic analysis of cholestatic liver damage in mice[J]. FOOD AND CHEMICAL TOXICOLOGY,2018,120:253-260.
APA Yang, Rui,Zhao, Qi,Hu, Dan-Dan,Xiao, Xue-Rong,Huang, Jian-Feng,&Li, Fei.(2018).Metabolomic analysis of cholestatic liver damage in mice.FOOD AND CHEMICAL TOXICOLOGY,120,253-260.
MLA Yang, Rui,et al."Metabolomic analysis of cholestatic liver damage in mice".FOOD AND CHEMICAL TOXICOLOGY 120(2018):253-260.
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