| Cytotoxic and N-Acetyltransferase Inhibitory Meroterpenoids from Ganoderma cochlear | |
| Cheng, Li-Zhi1,2; Qin, Fu-Ying2,3; Ma, Xiao-Chi4; Wang, Shu-Mei1; Yan, Yong-Ming2; Cheng, Yong-Xian1,2 | |
| 2018-07-01 | |
| 发表期刊 | MOLECULES
 |
| ISSN | 1420-3049 |
| 卷号 | 23期号:7页码:10 |
| 摘要 | Seven compounds, including two pairs of new meroterpenoids, (+)- and (-)-gancochlearol C (1), (+)- and (-)-cochlearoid Q (3), and a new meroterpenoid gancochlearol D (2), together with four known meroterpenoids were isolated from the aqueous EtOH extract of the fruiting bodies of Ganoderma cochlear. Their structures were determined by spectroscopic data. The isolated compounds were evaluated for their cytotoxic activity against three human lung cancer cells (H1975, PC9, A549) and N-acetyltransferase inhibitory property. The results show that (+)-gancochlearol C could inhibit N-acetyltransferase with an IC50 value of 5.29 M. In addition, ganomycin F was found to show moderate activity against the H1975 human lung cancer cell line, with an IC50 value of 19.47 M. |
| 关键词 | Ganoderma cochlear meroterpenoids cytotoxic activity N-acetyltransferase |
| DOI | 10.3390/molecules23071797 |
| 语种 | 英语 |
| WOS记录号 | WOS:000445301800300 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kib.ac.cn/handle/151853/62790 |
| 专题 | 植物化学与西部植物资源持续利用国家重点实验室 |
| 通讯作者 | Cheng, Yong-Xian |
| 作者单位 | 1.Guangdong Pharmaceut Univ, Sch Tradit Chinese Med, Guangzhou 510006, Guangdong, Peoples R China 2.Shenzhen Univ, Hlth Sci Ctr, Sch Pharmaceut Sci, Guangdong Key Lab Genome Stabil & Dis Prevent, Shenzhen 518060, Peoples R China 3.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 4.Dalian Med Univ, Sch Pharmaceut Sci, Dalian 116044, Peoples R China |
| 推荐引用方式 GB/T 7714 | Cheng, Li-Zhi,Qin, Fu-Ying,Ma, Xiao-Chi,et al. Cytotoxic and N-Acetyltransferase Inhibitory Meroterpenoids from Ganoderma cochlear[J]. MOLECULES,2018,23(7):10. |
| APA | Cheng, Li-Zhi,Qin, Fu-Ying,Ma, Xiao-Chi,Wang, Shu-Mei,Yan, Yong-Ming,&Cheng, Yong-Xian.(2018).Cytotoxic and N-Acetyltransferase Inhibitory Meroterpenoids from Ganoderma cochlear.MOLECULES,23(7),10. |
| MLA | Cheng, Li-Zhi,et al."Cytotoxic and N-Acetyltransferase Inhibitory Meroterpenoids from Ganoderma cochlear".MOLECULES 23.7(2018):10. |
| 条目包含的文件 | 条目无相关文件。 | |||||
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