Cytotoxic and N-Acetyltransferase Inhibitory Meroterpenoids from Ganoderma cochlear

doi:10.3390/molecules23071797

	Cytotoxic and N-Acetyltransferase Inhibitory Meroterpenoids from Ganoderma cochlear
	Cheng, Li-Zhi 1,2; Qin, Fu-Ying 2,3; Ma, Xiao-Chi 4; Wang, Shu-Mei 1; Yan, Yong-Ming 2; Cheng, Yong-Xian 1,2
	2018-07-01
发表期刊	MOLECULES
ISSN	1420-3049
卷号	23 期号:7 页码:10
摘要	Seven compounds, including two pairs of new meroterpenoids, (+)- and (-)-gancochlearol C (1), (+)- and (-)-cochlearoid Q (3), and a new meroterpenoid gancochlearol D (2), together with four known meroterpenoids were isolated from the aqueous EtOH extract of the fruiting bodies of Ganoderma cochlear. Their structures were determined by spectroscopic data. The isolated compounds were evaluated for their cytotoxic activity against three human lung cancer cells (H1975, PC9, A549) and N-acetyltransferase inhibitory property. The results show that (+)-gancochlearol C could inhibit N-acetyltransferase with an IC50 value of 5.29 M. In addition, ganomycin F was found to show moderate activity against the H1975 human lung cancer cell line, with an IC50 value of 19.47 M.
关键词	Ganoderma cochlear meroterpenoids cytotoxic activity N-acetyltransferase
DOI	10.3390/molecules23071797
语种	英语
WOS记录号	WOS:000445301800300
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/62790
专题	植物化学与西部植物资源持续利用国家重点实验室
通讯作者	Cheng, Yong-Xian
作者单位	1.Guangdong Pharmaceut Univ, Sch Tradit Chinese Med, Guangzhou 510006, Guangdong, Peoples R China 2.Shenzhen Univ, Hlth Sci Ctr, Sch Pharmaceut Sci, Guangdong Key Lab Genome Stabil & Dis Prevent, Shenzhen 518060, Peoples R China 3.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 4.Dalian Med Univ, Sch Pharmaceut Sci, Dalian 116044, Peoples R China
推荐引用方式 GB/T 7714	Cheng, Li-Zhi,Qin, Fu-Ying,Ma, Xiao-Chi,et al. Cytotoxic and N-Acetyltransferase Inhibitory Meroterpenoids from Ganoderma cochlear[J]. MOLECULES,2018,23(7):10.
APA	Cheng, Li-Zhi,Qin, Fu-Ying,Ma, Xiao-Chi,Wang, Shu-Mei,Yan, Yong-Ming,&Cheng, Yong-Xian.(2018).Cytotoxic and N-Acetyltransferase Inhibitory Meroterpenoids from Ganoderma cochlear.MOLECULES,23(7),10.
MLA	Cheng, Li-Zhi,et al."Cytotoxic and N-Acetyltransferase Inhibitory Meroterpenoids from Ganoderma cochlear".MOLECULES 23.7(2018):10.