Cytotoxic and N-Acetyltransferase Inhibitory Meroterpenoids from Ganoderma cochlear
Cheng, Li-Zhi1,2; Qin, Fu-Ying2,3; Ma, Xiao-Chi4; Wang, Shu-Mei1; Yan, Yong-Ming2; Cheng, Yong-Xian1,2
2018-07-01
Source PublicationMOLECULES
ISSN1420-3049
Volume23Issue:7Pages:10
AbstractSeven compounds, including two pairs of new meroterpenoids, (+)- and (-)-gancochlearol C (1), (+)- and (-)-cochlearoid Q (3), and a new meroterpenoid gancochlearol D (2), together with four known meroterpenoids were isolated from the aqueous EtOH extract of the fruiting bodies of Ganoderma cochlear. Their structures were determined by spectroscopic data. The isolated compounds were evaluated for their cytotoxic activity against three human lung cancer cells (H1975, PC9, A549) and N-acetyltransferase inhibitory property. The results show that (+)-gancochlearol C could inhibit N-acetyltransferase with an IC50 value of 5.29 M. In addition, ganomycin F was found to show moderate activity against the H1975 human lung cancer cell line, with an IC50 value of 19.47 M.
KeywordGanoderma cochlear meroterpenoids cytotoxic activity N-acetyltransferase
DOI10.3390/molecules23071797
Language英语
WOS Research AreaBiochemistry & Molecular Biology ; Chemistry
WOS SubjectBiochemistry & Molecular Biology ; Chemistry, Multidisciplinary
WOS IDWOS:000445301800300
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Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/62790
Collection植物化学与西部植物资源持续利用国家重点实验室
Corresponding AuthorCheng, Yong-Xian
Affiliation1.Guangdong Pharmaceut Univ, Sch Tradit Chinese Med, Guangzhou 510006, Guangdong, Peoples R China
2.Shenzhen Univ, Hlth Sci Ctr, Sch Pharmaceut Sci, Guangdong Key Lab Genome Stabil & Dis Prevent, Shenzhen 518060, Peoples R China
3.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
4.Dalian Med Univ, Sch Pharmaceut Sci, Dalian 116044, Peoples R China
Recommended Citation
GB/T 7714
Cheng, Li-Zhi,Qin, Fu-Ying,Ma, Xiao-Chi,et al. Cytotoxic and N-Acetyltransferase Inhibitory Meroterpenoids from Ganoderma cochlear[J]. MOLECULES,2018,23(7):10.
APA Cheng, Li-Zhi,Qin, Fu-Ying,Ma, Xiao-Chi,Wang, Shu-Mei,Yan, Yong-Ming,&Cheng, Yong-Xian.(2018).Cytotoxic and N-Acetyltransferase Inhibitory Meroterpenoids from Ganoderma cochlear.MOLECULES,23(7),10.
MLA Cheng, Li-Zhi,et al."Cytotoxic and N-Acetyltransferase Inhibitory Meroterpenoids from Ganoderma cochlear".MOLECULES 23.7(2018):10.
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