Cytotoxic and N-Acetyltransferase Inhibitory Meroterpenoids from Ganoderma cochlear
Cheng, Li-Zhi1,2; Qin, Fu-Ying2,3; Ma, Xiao-Chi4; Wang, Shu-Mei1; Yan, Yong-Ming2; Cheng, Yong-Xian1,2
2018-07-01
发表期刊MOLECULES
ISSN1420-3049
卷号23期号:7页码:10
摘要Seven compounds, including two pairs of new meroterpenoids, (+)- and (-)-gancochlearol C (1), (+)- and (-)-cochlearoid Q (3), and a new meroterpenoid gancochlearol D (2), together with four known meroterpenoids were isolated from the aqueous EtOH extract of the fruiting bodies of Ganoderma cochlear. Their structures were determined by spectroscopic data. The isolated compounds were evaluated for their cytotoxic activity against three human lung cancer cells (H1975, PC9, A549) and N-acetyltransferase inhibitory property. The results show that (+)-gancochlearol C could inhibit N-acetyltransferase with an IC50 value of 5.29 M. In addition, ganomycin F was found to show moderate activity against the H1975 human lung cancer cell line, with an IC50 value of 19.47 M.
关键词Ganoderma cochlear meroterpenoids cytotoxic activity N-acetyltransferase
资助信息National Key Research and Development Program of China; National Science Fund for Distinguished Young Scholars; NSFC-Joint Foundation of Yunnan Province; National Natural Science Foundation of China
语种英语
资助项目National Key Research and Development Program of China[2017YFA0503900] ; National Science Fund for Distinguished Young Scholars[81525026] ; NSFC-Joint Foundation of Yunnan Province[U1702287] ; National Natural Science Foundation of China[21472199]
引用统计
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/62790
专题植物化学与西部植物资源持续利用国家重点实验室
通讯作者Cheng, Yong-Xian
作者单位1.Guangdong Pharmaceut Univ, Sch Tradit Chinese Med, Guangzhou 510006, Guangdong, Peoples R China
2.Shenzhen Univ, Hlth Sci Ctr, Sch Pharmaceut Sci, Guangdong Key Lab Genome Stabil & Dis Prevent, Shenzhen 518060, Peoples R China
3.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
4.Dalian Med Univ, Sch Pharmaceut Sci, Dalian 116044, Peoples R China
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Cheng, Li-Zhi,Qin, Fu-Ying,Ma, Xiao-Chi,et al. Cytotoxic and N-Acetyltransferase Inhibitory Meroterpenoids from Ganoderma cochlear[J]. MOLECULES,2018,23(7):10.
APA Cheng, Li-Zhi,Qin, Fu-Ying,Ma, Xiao-Chi,Wang, Shu-Mei,Yan, Yong-Ming,&Cheng, Yong-Xian.(2018).Cytotoxic and N-Acetyltransferase Inhibitory Meroterpenoids from Ganoderma cochlear.MOLECULES,23(7),10.
MLA Cheng, Li-Zhi,et al."Cytotoxic and N-Acetyltransferase Inhibitory Meroterpenoids from Ganoderma cochlear".MOLECULES 23.7(2018):10.
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