Investigation on the Antibacterial and Anti-T3SS Activity of Traditional Myanmar Medicinal Plants
Li, Tianhong1; Zhang, Dongdong2,3; Oo, Thaung Naing4; San, Myint Myint4; Mon, Aye Mya2,3; Hein, Pyae Phyo2,3; Wang, Yuehu2; Lu, Chunhua1; Yang, Xuefei2,3
2018
发表期刊EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
ISSN1741-427X
页码13
摘要Myanmar has a rich pool of, but less known, medicinal plants with traditional knowledge. In this study, we aimed to investigate the inhibitory activity of traditional Myanmar medicinal plants against the type III secretion system (T355) of Salmonella enterica serovar Typhimurium UK-1 chi 8956 and the intestinal disease-caused by microbes including S. enterica serovar Typhimurium UK1 chi 8956, Proteusbacillus vulgaris CPCC 160013, Escherichia coli CICC 10003, and Staphylococcus aureus ATCC 25923. The EtOH extracts of 93 samples were used to screen the inhibitory activities against the secretion of T3SS effector proteins SipA/B/C/D of S. enterica and the antibacterial activity against S. enterica, P. vulgaris, E. coli, and S. aureus. Out of 71 crude drugs traditionally used, 18 were proofed to be effective either on the growth inhibition of tested bacteria and/or as inhibitors for the T3SS. The EtOH extracts of five plants, Luvunga scandens (Roxb.) Buch.-Ham. ex Wight & Arn. (My7), Myrica nagi Thunb. (My11), Terminalia citrina Roxb. ex Fleming (My21), Thymus vulgaris L. (My49), and Cinnamomum bejolghota (Buch.-Ham.) Sweet (My104), showed potent inhibitory activities against the secretion of T3SS proteins SipA/B/C/D of S. enterica serovar Typhimurium UK-1 chi 8956. Mansonia gagei J.R.Drumm (My3) and Mesua ferrea (Roxb.) L. (My10) showed strong antibacterial activities against P. vulgaris and S. aureus. This study provided the first scientific evidence of T3SS prohibiting and antibacterial properties for the traditional knowledge in Myanmar of using plants as medicines for treating infections and gastrointestinal disease. Further researches arc proposed to discover the active chemical compounds and mechanism of L. scandens (Roxb.) Buch.-Ham. ex Wight & Am, M. nagi Thunb., T. citrina Roxb. ex Fleming, T. vulgaris L., and C. bejolghota (Buch.-Ham.) Sweet as antivirulence drugs and the potential of M. gagei J.R.Drumm and M. ferrea L. as new broad spectrum plant antibiotics.
资助信息Southeast Asia Biodiversity Research Institute, Chinese Academy of Sciences; Program for Changjiang Scholars and Innovative Research Team in University
语种英语
资助项目Southeast Asia Biodiversity Research Institute, Chinese Academy of Sciences[2015CASEABRIRG001] ; Program for Changjiang Scholars and Innovative Research Team in University[IRT 17R68]
引用统计
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/62785
专题资源植物与生物技术所级重点实验室
通讯作者Lu, Chunhua; Yang, Xuefei
作者单位1.Shandong Univ, Sch Pharmaceut Sci, Key Lab Chem Biol, Minist Educ, Jinan 250012, Shandong, Peoples R China
2.Chinese Acad Sci, Kunming Inst Bot, Key Lab Econ Plants & Biotechnol, Kunming 650201, Yunnan, Peoples R China
3.Chinese Acad Sci, Southeast Asia Biodivers Res Inst, Yezin 05282, Nay Pyi Taw, Myanmar
4.Forest Res Inst, Yezin 05282, Nay Pyi Taw, Myanmar
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GB/T 7714
Li, Tianhong,Zhang, Dongdong,Oo, Thaung Naing,et al. Investigation on the Antibacterial and Anti-T3SS Activity of Traditional Myanmar Medicinal Plants[J]. EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE,2018:13.
APA Li, Tianhong.,Zhang, Dongdong.,Oo, Thaung Naing.,San, Myint Myint.,Mon, Aye Mya.,...&Yang, Xuefei.(2018).Investigation on the Antibacterial and Anti-T3SS Activity of Traditional Myanmar Medicinal Plants.EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE,13.
MLA Li, Tianhong,et al."Investigation on the Antibacterial and Anti-T3SS Activity of Traditional Myanmar Medicinal Plants".EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE (2018):13.
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