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Investigation on the Antibacterial and Anti-T3SS Activity of Traditional Myanmar Medicinal Plants
Li, Tianhong1; Zhang, Dongdong2,3; Oo, Thaung Naing4; San, Myint Myint4; Mon, Aye Mya2,3; Hein, Pyae Phyo2,3; Wang, Yuehu2; Lu, Chunhua1; Yang, Xuefei2,3
2018
Source PublicationEVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
ISSN1741-427X
Pages13
Abstract

Myanmar has a rich pool of, but less known, medicinal plants with traditional knowledge. In this study, we aimed to investigate the inhibitory activity of traditional Myanmar medicinal plants against the type III secretion system (T355) of Salmonella enterica serovar Typhimurium UK-1 chi 8956 and the intestinal disease-caused by microbes including S. enterica serovar Typhimurium UK1 chi 8956, Proteusbacillus vulgaris CPCC 160013, Escherichia coli CICC 10003, and Staphylococcus aureus ATCC 25923. The EtOH extracts of 93 samples were used to screen the inhibitory activities against the secretion of T3SS effector proteins SipA/B/C/D of S. enterica and the antibacterial activity against S. enterica, P. vulgaris, E. coli, and S. aureus. Out of 71 crude drugs traditionally used, 18 were proofed to be effective either on the growth inhibition of tested bacteria and/or as inhibitors for the T3SS. The EtOH extracts of five plants, Luvunga scandens (Roxb.) Buch.-Ham. ex Wight & Arn. (My7), Myrica nagi Thunb. (My11), Terminalia citrina Roxb. ex Fleming (My21), Thymus vulgaris L. (My49), and Cinnamomum bejolghota (Buch.-Ham.) Sweet (My104), showed potent inhibitory activities against the secretion of T3SS proteins SipA/B/C/D of S. enterica serovar Typhimurium UK-1 chi 8956. Mansonia gagei J.R.Drumm (My3) and Mesua ferrea (Roxb.) L. (My10) showed strong antibacterial activities against P. vulgaris and S. aureus. This study provided the first scientific evidence of T3SS prohibiting and antibacterial properties for the traditional knowledge in Myanmar of using plants as medicines for treating infections and gastrointestinal disease. Further researches arc proposed to discover the active chemical compounds and mechanism of L. scandens (Roxb.) Buch.-Ham. ex Wight & Am, M. nagi Thunb., T. citrina Roxb. ex Fleming, T. vulgaris L., and C. bejolghota (Buch.-Ham.) Sweet as antivirulence drugs and the potential of M. gagei J.R.Drumm and M. ferrea L. as new broad spectrum plant antibiotics.

DOI10.1155/2018/2812908
Language英语
WOS Research AreaIntegrative & Complementary Medicine
WOS SubjectIntegrative & Complementary Medicine
WOS IDWOS:000447898400001
Citation statistics
Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/62785
Collection资源植物与生物技术所级重点实验室
Corresponding AuthorLu, Chunhua; Yang, Xuefei
Affiliation1.Shandong Univ, Sch Pharmaceut Sci, Key Lab Chem Biol, Minist Educ, Jinan 250012, Shandong, Peoples R China
2.Chinese Acad Sci, Kunming Inst Bot, Key Lab Econ Plants & Biotechnol, Kunming 650201, Yunnan, Peoples R China
3.Chinese Acad Sci, Southeast Asia Biodivers Res Inst, Yezin 05282, Nay Pyi Taw, Myanmar
4.Forest Res Inst, Yezin 05282, Nay Pyi Taw, Myanmar
Recommended Citation
GB/T 7714
Li, Tianhong,Zhang, Dongdong,Oo, Thaung Naing,et al. Investigation on the Antibacterial and Anti-T3SS Activity of Traditional Myanmar Medicinal Plants[J]. EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE,2018:13.
APA Li, Tianhong.,Zhang, Dongdong.,Oo, Thaung Naing.,San, Myint Myint.,Mon, Aye Mya.,...&Yang, Xuefei.(2018).Investigation on the Antibacterial and Anti-T3SS Activity of Traditional Myanmar Medicinal Plants.EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE,13.
MLA Li, Tianhong,et al."Investigation on the Antibacterial and Anti-T3SS Activity of Traditional Myanmar Medicinal Plants".EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE (2018):13.
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