| Total Synthesis of Asperchalasines A, D, E, and H | |
| Long, Xianwen1,2,3; Ding, Yiming1,2; Deng, Jun1,2 | |
| 2018-10-22 | |
| 发表期刊 | ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
 |
| ISSN | 1433-7851 |
| 卷号 | 57期号:43页码:14221-14224 |
| 摘要 | The first total syntheses of the cytochalasan dimers asperchalasines A, D, E, and H have been accomplished. The key steps of the synthesis include a highly stereoselective intermolecular Diels-Alder reaction and a Horner-Wads-worth-Emmons macrocyclization to establish the key monomer aspochalasin B, and an intermolecular Diels-Alder reaction followed by a biomimetic oxidative heterodimerization by 5+2 cycloaddition to furnish asperchalasine A. The synthetic efforts provide insight into the biosynthetic pathway of cytochalasan dimers and enables the further study of their biological properties. |
| 关键词 | biomimetic synthesis cycloaddition dimers natural products total synthesis |
| DOI | 10.1002/anie.201808481 |
| 语种 | 英语 |
| WOS记录号 | WOS:000447371500043 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kib.ac.cn/handle/151853/62773 |
| 专题 | 植物化学与西部植物资源持续利用国家重点实验室 |
| 通讯作者 | Deng, Jun |
| 作者单位 | 1.Chinese Acad Sci, Dept State Key Lab Phytochem & Plant Resources We, 132 Lanhei Rd, Kunming 650201, Yunnan, Peoples R China 2.Chinese Acad Sci, Yunnan Key Lab Nat Med Chem, Kunming Inst Bot, 132 Lanhei Rd, Kunming 650201, Yunnan, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Long, Xianwen,Ding, Yiming,Deng, Jun. Total Synthesis of Asperchalasines A, D, E, and H[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,2018,57(43):14221-14224. |
| APA | Long, Xianwen,Ding, Yiming,&Deng, Jun.(2018).Total Synthesis of Asperchalasines A, D, E, and H.ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,57(43),14221-14224. |
| MLA | Long, Xianwen,et al."Total Synthesis of Asperchalasines A, D, E, and H".ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 57.43(2018):14221-14224. |
| 条目包含的文件 | 条目无相关文件。 | |||||
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