Total Synthesis of Asperchalasines A, D, E, and H
Long, Xianwen1,2,3; Ding, Yiming1,2; Deng, Jun1,2
2018-10-22
发表期刊ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
ISSN1433-7851
卷号57期号:43页码:14221-14224
摘要The first total syntheses of the cytochalasan dimers asperchalasines A, D, E, and H have been accomplished. The key steps of the synthesis include a highly stereoselective intermolecular Diels-Alder reaction and a Horner-Wads-worth-Emmons macrocyclization to establish the key monomer aspochalasin B, and an intermolecular Diels-Alder reaction followed by a biomimetic oxidative heterodimerization by 5+2 cycloaddition to furnish asperchalasine A. The synthetic efforts provide insight into the biosynthetic pathway of cytochalasan dimers and enables the further study of their biological properties.
关键词biomimetic synthesis cycloaddition dimers natural products total synthesis
资助信息CAS Pioneer Hundred Talents Program; National Natural Science Foundaion of China; Kunming Institute of Botany
语种英语
资助项目CAS Pioneer Hundred Talents Program[2017-022] ; National Natural Science Foundaion of China[21871278] ; Kunming Institute of Botany
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文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/62773
专题植物化学与西部植物资源持续利用国家重点实验室
通讯作者Deng, Jun
作者单位1.Chinese Acad Sci, Dept State Key Lab Phytochem & Plant Resources We, 132 Lanhei Rd, Kunming 650201, Yunnan, Peoples R China
2.Chinese Acad Sci, Yunnan Key Lab Nat Med Chem, Kunming Inst Bot, 132 Lanhei Rd, Kunming 650201, Yunnan, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
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Long, Xianwen,Ding, Yiming,Deng, Jun. Total Synthesis of Asperchalasines A, D, E, and H[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,2018,57(43):14221-14224.
APA Long, Xianwen,Ding, Yiming,&Deng, Jun.(2018).Total Synthesis of Asperchalasines A, D, E, and H.ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,57(43),14221-14224.
MLA Long, Xianwen,et al."Total Synthesis of Asperchalasines A, D, E, and H".ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 57.43(2018):14221-14224.
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