Total Synthesis of Asperchalasines A, D, E, and H

doi:10.1002/anie.201808481

	Total Synthesis of Asperchalasines A, D, E, and H
	Long, Xianwen 1,2,3; Ding, Yiming 1,2; Deng, Jun 1,2
	2018-10-22
发表期刊	ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
ISSN	1433-7851
卷号	57 期号:43 页码:14221-14224
摘要	The first total syntheses of the cytochalasan dimers asperchalasines A, D, E, and H have been accomplished. The key steps of the synthesis include a highly stereoselective intermolecular Diels-Alder reaction and a Horner-Wads-worth-Emmons macrocyclization to establish the key monomer aspochalasin B, and an intermolecular Diels-Alder reaction followed by a biomimetic oxidative heterodimerization by 5+2 cycloaddition to furnish asperchalasine A. The synthetic efforts provide insight into the biosynthetic pathway of cytochalasan dimers and enables the further study of their biological properties.
关键词	biomimetic synthesis cycloaddition dimers natural products total synthesis
DOI	10.1002/anie.201808481
语种	英语
WOS记录号	WOS:000447371500043
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/62773
专题	植物化学与西部植物资源持续利用国家重点实验室
通讯作者	Deng, Jun
作者单位	1.Chinese Acad Sci, Dept State Key Lab Phytochem & Plant Resources We, 132 Lanhei Rd, Kunming 650201, Yunnan, Peoples R China 2.Chinese Acad Sci, Yunnan Key Lab Nat Med Chem, Kunming Inst Bot, 132 Lanhei Rd, Kunming 650201, Yunnan, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Long, Xianwen,Ding, Yiming,Deng, Jun. Total Synthesis of Asperchalasines A, D, E, and H[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,2018,57(43):14221-14224.
APA	Long, Xianwen,Ding, Yiming,&Deng, Jun.(2018).Total Synthesis of Asperchalasines A, D, E, and H.ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,57(43),14221-14224.
MLA	Long, Xianwen,et al."Total Synthesis of Asperchalasines A, D, E, and H".ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 57.43(2018):14221-14224.