Cimitriteromone A-G, Macromolecular Triterpenoid-Chromone Hybrids from the Rhizomes of Cimicifuga foetida
Shi, Qiang-Qiang1,2,3; Lu, Jing1,2,3; Peng, Xing-Rong1,3; Li, Da-Shan1,3; Zhou, Lin1,3; Qiu, Ming-Hua1,2,3
2018-09-07
发表期刊JOURNAL OF ORGANIC CHEMISTRY
ISSN0022-3263
卷号83期号:17页码:10359-10369
摘要Seven unprecedented high molecular weight hybrids of cycloartane triterpenoid saponins and chromone glycosides, namely, Cimitriteromone A-G (1-7), and three known biogenetic precursors (8-10) were isolated from the rhizomes of Cimicifuga foetida by using the HPLC-UV/MS method. The structures of the new compounds were determined by NMR analysis and HRESIMS data. The absolute configurations of sugar moieties were established by a chemical method. The new compounds 2 and 4 showed antiproliferative activities against Taxol-resistant human lung cancer A-549/Taxol with IC50 values of 15.73 +/- 0.59 and 24.21 +/- 0.61 mu M, respectively, while the positive control groups cisplatin and Taxol gave IC50 values of 25.80 +/- 1.15 and 0.60 +/- 0.09 mu M. Notably, compound 4 showed comparable cytotoxicity to the positive control, cisplatin, whereas the corresponding biogenetic precursors compounds 8 and 10 were inactive (IC50 > 40 mu M).
资助信息Autonomous Deployment Project of the Kunming Institute of Botany, CAS; Programs of National Natural Science Foundation of China; Major Program of CAS
语种英语
资助项目Autonomous Deployment Project of the Kunming Institute of Botany, CAS[KIB2017010] ; Programs of National Natural Science Foundation of China[U1132604] ; Programs of National Natural Science Foundation of China[81302670] ; Major Program of CAS[KSZD-EW-Z-004-01]
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文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/62429
专题植物化学与西部植物资源持续利用国家重点实验室
通讯作者Qiu, Ming-Hua
作者单位1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.Chinese Acad Sci, Yunnan Key Lab Nat Med Chem, Kunming 650201, Yunnan, Peoples R China
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Shi, Qiang-Qiang,Lu, Jing,Peng, Xing-Rong,et al. Cimitriteromone A-G, Macromolecular Triterpenoid-Chromone Hybrids from the Rhizomes of Cimicifuga foetida[J]. JOURNAL OF ORGANIC CHEMISTRY,2018,83(17):10359-10369.
APA Shi, Qiang-Qiang,Lu, Jing,Peng, Xing-Rong,Li, Da-Shan,Zhou, Lin,&Qiu, Ming-Hua.(2018).Cimitriteromone A-G, Macromolecular Triterpenoid-Chromone Hybrids from the Rhizomes of Cimicifuga foetida.JOURNAL OF ORGANIC CHEMISTRY,83(17),10359-10369.
MLA Shi, Qiang-Qiang,et al."Cimitriteromone A-G, Macromolecular Triterpenoid-Chromone Hybrids from the Rhizomes of Cimicifuga foetida".JOURNAL OF ORGANIC CHEMISTRY 83.17(2018):10359-10369.
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