| Hericinoids A-C, cyathane diterpenoids from culture of mushroom Hericium erinaceus | |
| Chen, Lin1; Yao, Jian-Neng2,3; Chen, He-Ping1; Zhao, Zhen-Zhu1; Li, Zheng-Hui1; Feng, Tao1; Liu, Ji-Kai1 | |
| 2018-10-01 | |
| Source Publication | PHYTOCHEMISTRY LETTERS
 |
| ISSN | 1874-3900 |
| Volume | 27Pages:94-100 |
| Abstract | Three previously undescribed cyathane-type diterpenoids, hericinoids A-C (1-3) and three known analogues (4-6) have been isolated from fermentation broth of Hericium erinaceus. Their structures of hericinoids A-C were determined by in-depth analyses of NMR spectra and HRESIMS. The absolute configurations of compounds 1 and 2 were determined by the ROESY spectra along with the DP4+ calculations based on quantum chemistry. Compounds 1-5 were inactive on the enhancement of NGF-induced neutrite outgrowth in PC-12 cells. Instead, compounds 2, 4, and 5 showed potent cytotoxicity against HL-60 cell lines with the IC50 values of 18.3, 8.9, and 0.5 mu M, respectively. Compounds 4 and 5 showed moderate cytotoxicities against MCF-7 cell lines with the IC50 values ranging from 13.4 to 15.8 mu M. |
| Keyword | Hericium erinaceus Cyathane diterpenoid Cytotoxic activity DP4 plus |
| DOI | 10.1016/j.phytol.2018.07.006 |
| Language | 英语 |
| WOS ID | WOS:000445267500019 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.kib.ac.cn/handle/151853/62427 |
| Collection | 植物化学与西部植物资源持续利用国家重点实验室 |
| Corresponding Author | Feng, Tao; Liu, Ji-Kai |
| Affiliation | 1.South Cent Univ Nationalities, Sch Pharmaceut Sci, Wuhan 430074, Hubei, Peoples R China 2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| Recommended Citation GB/T 7714 | Chen, Lin,Yao, Jian-Neng,Chen, He-Ping,et al. Hericinoids A-C, cyathane diterpenoids from culture of mushroom Hericium erinaceus[J]. PHYTOCHEMISTRY LETTERS,2018,27:94-100. |
| APA | Chen, Lin.,Yao, Jian-Neng.,Chen, He-Ping.,Zhao, Zhen-Zhu.,Li, Zheng-Hui.,...&Liu, Ji-Kai.(2018).Hericinoids A-C, cyathane diterpenoids from culture of mushroom Hericium erinaceus.PHYTOCHEMISTRY LETTERS,27,94-100. |
| MLA | Chen, Lin,et al."Hericinoids A-C, cyathane diterpenoids from culture of mushroom Hericium erinaceus".PHYTOCHEMISTRY LETTERS 27(2018):94-100. |
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