Hericinoids A-C, cyathane diterpenoids from culture of mushroom Hericium erinaceus
Chen, Lin1; Yao, Jian-Neng2,3; Chen, He-Ping1; Zhao, Zhen-Zhu1; Li, Zheng-Hui1; Feng, Tao1; Liu, Ji-Kai1
2018-10-01
发表期刊PHYTOCHEMISTRY LETTERS
ISSN1874-3900
卷号27页码:94-100
摘要Three previously undescribed cyathane-type diterpenoids, hericinoids A-C (1-3) and three known analogues (4-6) have been isolated from fermentation broth of Hericium erinaceus. Their structures of hericinoids A-C were determined by in-depth analyses of NMR spectra and HRESIMS. The absolute configurations of compounds 1 and 2 were determined by the ROESY spectra along with the DP4+ calculations based on quantum chemistry. Compounds 1-5 were inactive on the enhancement of NGF-induced neutrite outgrowth in PC-12 cells. Instead, compounds 2, 4, and 5 showed potent cytotoxicity against HL-60 cell lines with the IC50 values of 18.3, 8.9, and 0.5 mu M, respectively. Compounds 4 and 5 showed moderate cytotoxicities against MCF-7 cell lines with the IC50 values ranging from 13.4 to 15.8 mu M.
关键词Hericium erinaceus Cyathane diterpenoid Cytotoxic activity DP4 plus
资助信息National Key Research and Development Program of China; National Natural Science Foundation of China; Key Projects of Technological Innovation of Hubei Province; Fundamental Research Funds for the Central University, South-Central University for Nationalities
DOI10.1016/j.phytol.2018.07.006
语种英语
资助项目National Key Research and Development Program of China[2017YFC1704007] ; National Natural Science Foundation of China[81773590] ; National Natural Science Foundation of China[81561148013] ; Key Projects of Technological Innovation of Hubei Province[2016ACA138] ; Fundamental Research Funds for the Central University, South-Central University for Nationalities[CZP18005] ; Fundamental Research Funds for the Central University, South-Central University for Nationalities[CZQ17010] ; Fundamental Research Funds for the Central University, South-Central University for Nationalities[CZQ17008] ; Fundamental Research Funds for the Central University, South-Central University for Nationalities[CZT18014] ; Fundamental Research Funds for the Central University, South-Central University for Nationalities[CZT18013]
WOS研究方向Plant Sciences ; Pharmacology & Pharmacy
WOS类目Plant Sciences ; Chemistry, Medicinal
WOS记录号WOS:000445267500019
出版者ELSEVIER SCIENCE BV
引用统计
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/62427
专题植物化学与西部植物资源持续利用国家重点实验室
通讯作者Feng, Tao; Liu, Ji-Kai
作者单位1.South Cent Univ Nationalities, Sch Pharmaceut Sci, Wuhan 430074, Hubei, Peoples R China
2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
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GB/T 7714
Chen, Lin,Yao, Jian-Neng,Chen, He-Ping,et al. Hericinoids A-C, cyathane diterpenoids from culture of mushroom Hericium erinaceus[J]. PHYTOCHEMISTRY LETTERS,2018,27:94-100.
APA Chen, Lin.,Yao, Jian-Neng.,Chen, He-Ping.,Zhao, Zhen-Zhu.,Li, Zheng-Hui.,...&Liu, Ji-Kai.(2018).Hericinoids A-C, cyathane diterpenoids from culture of mushroom Hericium erinaceus.PHYTOCHEMISTRY LETTERS,27,94-100.
MLA Chen, Lin,et al."Hericinoids A-C, cyathane diterpenoids from culture of mushroom Hericium erinaceus".PHYTOCHEMISTRY LETTERS 27(2018):94-100.
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