Heterocyclic Compounds from the Mushroom Albatrellus confluens and Their Inhibitions against Lipopolysaccharides-Induced B Lymphocyte Cell Proliferation
Zhang, Shuaibing1,2,3; Huang, Ying1,2,3; He, Shijun4; Chen, Heping1; Wu, Bin1; Li, Shanyong2,3; Zhao, Zhenzhu2,3; Li, Zhenghui1; Wang, Xian1; Zuo, Jianping4; Feng, Tao1; Liu, Jikai1
2018-09-07
发表期刊JOURNAL OF ORGANIC CHEMISTRY
ISSN0022-3263
卷号83期号:17页码:10158-10165
摘要Eight hetereocyclic compounds conflamides B-I with an unprecedented skeleton and their precursor conflamide A were isolated from the mushroom Albatrellus confluens. Their structures and absolute configurations were determined by use of NMR studies, total synthesis, and calculated ECD spectra. Conflamides D and E were found to exhibit potent inhibition against LPS-induced B lymphocyte cell proliferation with IC50 values 1.48 and 5.71 mu M, respectively.
资助信息National Key Research and Development Program of China; National Natural Science Foundation of China; Thailand Research Fund; Key Projects of Technological Innovation of Hubei Province; Fundamental Research Funds for the Central University; South-Central University for Nationalities
DOI10.1021/acs.joc.8b01420
语种英语
资助项目National Key Research and Development Program of China[2017YFC1704007] ; National Natural Science Foundation of China[81773590] ; National Natural Science Foundation of China[81561148013] ; Thailand Research Fund[DBGS980002] ; Key Projects of Technological Innovation of Hubei Province[2016ACA138] ; Fundamental Research Funds for the Central University ; South-Central University for Nationalities[CZP18005] ; South-Central University for Nationalities[CZQ17010] ; South-Central University for Nationalities[CZQ17008] ; South-Central University for Nationalities[CZT18014] ; South-Central University for Nationalities[CZT18013]
WOS研究方向Chemistry
WOS类目Chemistry, Organic
WOS记录号WOS:000444364600049
出版者AMER CHEMICAL SOC
引用统计
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/62420
专题植物化学与西部植物资源持续利用国家重点实验室
通讯作者Zuo, Jianping; Feng, Tao; Liu, Jikai
作者单位1.South Cent Univ Nationalities, Sch Pharmaceut Sci, Wuhan 430074, Hubei, Peoples R China
2.Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
4.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China
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Zhang, Shuaibing,Huang, Ying,He, Shijun,et al. Heterocyclic Compounds from the Mushroom Albatrellus confluens and Their Inhibitions against Lipopolysaccharides-Induced B Lymphocyte Cell Proliferation[J]. JOURNAL OF ORGANIC CHEMISTRY,2018,83(17):10158-10165.
APA Zhang, Shuaibing.,Huang, Ying.,He, Shijun.,Chen, Heping.,Wu, Bin.,...&Liu, Jikai.(2018).Heterocyclic Compounds from the Mushroom Albatrellus confluens and Their Inhibitions against Lipopolysaccharides-Induced B Lymphocyte Cell Proliferation.JOURNAL OF ORGANIC CHEMISTRY,83(17),10158-10165.
MLA Zhang, Shuaibing,et al."Heterocyclic Compounds from the Mushroom Albatrellus confluens and Their Inhibitions against Lipopolysaccharides-Induced B Lymphocyte Cell Proliferation".JOURNAL OF ORGANIC CHEMISTRY 83.17(2018):10158-10165.
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