Belamchinanes A-D from Belamcanda chinensis: Triterpenoids with an Unprecedented Carbon Skeleton and Their Activity against Age-Related Renal Fibrosis

doi:10.1021/acs.orglett.8b02490

	Belamchinanes A-D from Belamcanda chinensis: Triterpenoids with an Unprecedented Carbon Skeleton and Their Activity against Age-Related Renal Fibrosis
	Song, Ying-Ying 2,4; Miao, Jin-Hua 3; Qin, Fu-Ying 1,2,4; Yan, Yong-Ming 1; Yang, Jing2 ; Qin, Da-Peng 1; Hou, Fan-Fan 3; Zhou, Li-Li 3; Cheng, Yong-Xian 1
	2018-09-07
发表期刊	ORGANIC LETTERS
ISSN	1523-7060
卷号	20 期号:17 页码:5506-5509
摘要	Belamchinanes A-D (1-4), four triterpenoids with an unprecedented skeleton, were isolated from the seeds of Belamcanda chinensis and fully characterized. The structures of belamchinanes feature a 4/6/6/6/5 polycyclic system in which a four-membered carbocyclic ring bridges the C-1 and C-11 positions of a classical triterpenoid framework. A plausible pathway for the biosynthesis of 1-4 is proposed. Biological studies reveal that 1-4 dose-dependently protect age-related renal fibrosis in vitro.
DOI	10.1021/acs.orglett.8b02490
语种	英语
WOS记录号	WOS:000444527000098
引用统计	被引频次：12[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/62418
专题	植物化学与西部植物资源持续利用国家重点实验室
通讯作者	Hou, Fan-Fan; Zhou, Li-Li; Cheng, Yong-Xian
作者单位	1.Shenzhen Univ, Hlth Sci Ctr, Sch Pharmaceut Sci, Guangdong Key Lab Genome Stabil & Dis Prevent, Shenzhen 518060, Peoples R China 2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 3.Southern Med Univ, Nanfang Hosp, Guangdong Prov Inst Nephrol, State Key Lab Organ Failure Res,Div Nephrol, Guangzhou 510515, Guangdong, Peoples R China 4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Song, Ying-Ying,Miao, Jin-Hua,Qin, Fu-Ying,et al. Belamchinanes A-D from Belamcanda chinensis: Triterpenoids with an Unprecedented Carbon Skeleton and Their Activity against Age-Related Renal Fibrosis[J]. ORGANIC LETTERS,2018,20(17):5506-5509.
APA	Song, Ying-Ying.,Miao, Jin-Hua.,Qin, Fu-Ying.,Yan, Yong-Ming.,Yang, Jing.,...&Cheng, Yong-Xian.(2018).Belamchinanes A-D from Belamcanda chinensis: Triterpenoids with an Unprecedented Carbon Skeleton and Their Activity against Age-Related Renal Fibrosis.ORGANIC LETTERS,20(17),5506-5509.
MLA	Song, Ying-Ying,et al."Belamchinanes A-D from Belamcanda chinensis: Triterpenoids with an Unprecedented Carbon Skeleton and Their Activity against Age-Related Renal Fibrosis".ORGANIC LETTERS 20.17(2018):5506-5509.