Belamchinanes A-D from Belamcanda chinensis: Triterpenoids with an Unprecedented Carbon Skeleton and Their Activity against Age-Related Renal Fibrosis
Song, Ying-Ying2,4; Miao, Jin-Hua3; Qin, Fu-Ying1,2,4; Yan, Yong-Ming1; Yang, Jing2; Qin, Da-Peng1; Hou, Fan-Fan3; Zhou, Li-Li3; Cheng, Yong-Xian1
2018-09-07
发表期刊ORGANIC LETTERS
ISSN1523-7060
卷号20期号:17页码:5506-5509
摘要Belamchinanes A-D (1-4), four triterpenoids with an unprecedented skeleton, were isolated from the seeds of Belamcanda chinensis and fully characterized. The structures of belamchinanes feature a 4/6/6/6/5 polycyclic system in which a four-membered carbocyclic ring bridges the C-1 and C-11 positions of a classical triterpenoid framework. A plausible pathway for the biosynthesis of 1-4 is proposed. Biological studies reveal that 1-4 dose-dependently protect age-related renal fibrosis in vitro.
资助信息National Science Fund for Distinguished Young Scholars; National Key Research and Development Program of China; National Natural Science Foundation of China
DOI10.1021/acs.orglett.8b02490
语种英语
资助项目National Science Fund for Distinguished Young Scholars[81525026] ; National Key Research and Development Program of China[2017YFA0503900] ; National Natural Science Foundation of China[81722011] ; National Natural Science Foundation of China[81521003] ; National Natural Science Foundation of China[81570620]
WOS研究方向Chemistry
WOS类目Chemistry, Organic
WOS记录号WOS:000444527000098
出版者AMER CHEMICAL SOC
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文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/62418
专题植物化学与西部植物资源持续利用国家重点实验室
通讯作者Hou, Fan-Fan; Zhou, Li-Li; Cheng, Yong-Xian
作者单位1.Shenzhen Univ, Hlth Sci Ctr, Sch Pharmaceut Sci, Guangdong Key Lab Genome Stabil & Dis Prevent, Shenzhen 518060, Peoples R China
2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
3.Southern Med Univ, Nanfang Hosp, Guangdong Prov Inst Nephrol, State Key Lab Organ Failure Res,Div Nephrol, Guangzhou 510515, Guangdong, Peoples R China
4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
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Song, Ying-Ying,Miao, Jin-Hua,Qin, Fu-Ying,et al. Belamchinanes A-D from Belamcanda chinensis: Triterpenoids with an Unprecedented Carbon Skeleton and Their Activity against Age-Related Renal Fibrosis[J]. ORGANIC LETTERS,2018,20(17):5506-5509.
APA Song, Ying-Ying.,Miao, Jin-Hua.,Qin, Fu-Ying.,Yan, Yong-Ming.,Yang, Jing.,...&Cheng, Yong-Xian.(2018).Belamchinanes A-D from Belamcanda chinensis: Triterpenoids with an Unprecedented Carbon Skeleton and Their Activity against Age-Related Renal Fibrosis.ORGANIC LETTERS,20(17),5506-5509.
MLA Song, Ying-Ying,et al."Belamchinanes A-D from Belamcanda chinensis: Triterpenoids with an Unprecedented Carbon Skeleton and Their Activity against Age-Related Renal Fibrosis".ORGANIC LETTERS 20.17(2018):5506-5509.
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