Meroterpenoid dimers from Ganoderma cochlear and their cytotoxic and COX-2 inhibitory activities

doi:10.1016/j.fitote.2018.06.019

	Meroterpenoid dimers from Ganoderma cochlear and their cytotoxic and COX-2 inhibitory activities
	Qin, Fu-Ying 1,2,3; Yan, Yong-Ming 2; Tu, Zheng-Chao 4; Cheng, Yong-Xian 1,2,5
	2018-09-01
发表期刊	FITOTERAPIA
ISSN	0367-326X
卷号	129 页码:167-172
摘要	(+)- and (-)-Spirocochlealactones A-C (1-3), three pairs of new spiro meroterpenoidal dimeric enantiomers together with one known compound ganodilactone (4), were isolated from the fruiting bodies of Ganoderma cochlear. Their structures including absolute configurations were assigned by using spectroscopic methods and ECD calculations. All the isolated compounds were tested for their COX-2 inhibitory and cytotoxic activities toward human cancer lines (A549, K562, and Huh-7). The results show that all the compounds could inhibit COX-2 with IC50 values in the range of 1.29 to 3.63 mu M. In addition, (+)-spirocochlealactone A and (+)-ganodilactone were found to be moderate activities against human cancer cell line A549 with the IC50 values of 7.14 and 9.47 mu M, respectively.
关键词	Ganoderma cochlear Meroterpenoids Computational methods Cytotoxicity COX-2
DOI	10.1016/j.fitote.2018.06.019
语种	英语
WOS记录号	WOS:000443663800025
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/62299
专题	植物化学与西部植物资源持续利用国家重点实验室
通讯作者	Cheng, Yong-Xian
作者单位	1.Henan Univ Chinese Med, Coll Pharm, Zhengzhou 450008, Henan, Peoples R China 2.Shenzhen Univ, Sch Pharmaceut Sci, Guangdong Key Lab Genome Stabil & Dis Prevent, Hlth Sci Ctr, Shenzhen 518060, Peoples R China 3.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 4.Chinese Acad Sci, Guangzhou Inst Biomed & Hlth, Guangzhou 510530, Guangdong, Peoples R China 5.Shenzhen Univ, Hlth Sci Ctr, Sch Pharmaceut Sci, Shenzhen 518060, Peoples R China
推荐引用方式 GB/T 7714	Qin, Fu-Ying,Yan, Yong-Ming,Tu, Zheng-Chao,et al. Meroterpenoid dimers from Ganoderma cochlear and their cytotoxic and COX-2 inhibitory activities[J]. FITOTERAPIA,2018,129:167-172.
APA	Qin, Fu-Ying,Yan, Yong-Ming,Tu, Zheng-Chao,&Cheng, Yong-Xian.(2018).Meroterpenoid dimers from Ganoderma cochlear and their cytotoxic and COX-2 inhibitory activities.FITOTERAPIA,129,167-172.
MLA	Qin, Fu-Ying,et al."Meroterpenoid dimers from Ganoderma cochlear and their cytotoxic and COX-2 inhibitory activities".FITOTERAPIA 129(2018):167-172.