Meroterpenoid dimers from Ganoderma cochlear and their cytotoxic and COX-2 inhibitory activities
Qin, Fu-Ying1,2,3; Yan, Yong-Ming2; Tu, Zheng-Chao4; Cheng, Yong-Xian1,2,5
2018-09-01
Source PublicationFITOTERAPIA
ISSN0367-326X
Volume129Pages:167-172
Abstract(+)- and (-)-Spirocochlealactones A-C (1-3), three pairs of new spiro meroterpenoidal dimeric enantiomers together with one known compound ganodilactone (4), were isolated from the fruiting bodies of Ganoderma cochlear. Their structures including absolute configurations were assigned by using spectroscopic methods and ECD calculations. All the isolated compounds were tested for their COX-2 inhibitory and cytotoxic activities toward human cancer lines (A549, K562, and Huh-7). The results show that all the compounds could inhibit COX-2 with IC50 values in the range of 1.29 to 3.63 mu M. In addition, (+)-spirocochlealactone A and (+)-ganodilactone were found to be moderate activities against human cancer cell line A549 with the IC50 values of 7.14 and 9.47 mu M, respectively.
KeywordGanoderma cochlear Meroterpenoids Computational methods Cytotoxicity COX-2
DOI10.1016/j.fitote.2018.06.019
Language英语
WOS Research AreaPharmacology & Pharmacy
WOS SubjectChemistry, Medicinal ; Pharmacology & Pharmacy
WOS IDWOS:000443663800025
Citation statistics
Cited Times:2[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/62299
Collection植物化学与西部植物资源持续利用国家重点实验室
Corresponding AuthorCheng, Yong-Xian
Affiliation1.Henan Univ Chinese Med, Coll Pharm, Zhengzhou 450008, Henan, Peoples R China
2.Shenzhen Univ, Sch Pharmaceut Sci, Guangdong Key Lab Genome Stabil & Dis Prevent, Hlth Sci Ctr, Shenzhen 518060, Peoples R China
3.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
4.Chinese Acad Sci, Guangzhou Inst Biomed & Hlth, Guangzhou 510530, Guangdong, Peoples R China
5.Shenzhen Univ, Hlth Sci Ctr, Sch Pharmaceut Sci, Shenzhen 518060, Peoples R China
Recommended Citation
GB/T 7714
Qin, Fu-Ying,Yan, Yong-Ming,Tu, Zheng-Chao,et al. Meroterpenoid dimers from Ganoderma cochlear and their cytotoxic and COX-2 inhibitory activities[J]. FITOTERAPIA,2018,129:167-172.
APA Qin, Fu-Ying,Yan, Yong-Ming,Tu, Zheng-Chao,&Cheng, Yong-Xian.(2018).Meroterpenoid dimers from Ganoderma cochlear and their cytotoxic and COX-2 inhibitory activities.FITOTERAPIA,129,167-172.
MLA Qin, Fu-Ying,et al."Meroterpenoid dimers from Ganoderma cochlear and their cytotoxic and COX-2 inhibitory activities".FITOTERAPIA 129(2018):167-172.
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