Meroterpenoid dimers from Ganoderma cochlear and their cytotoxic and COX-2 inhibitory activities
Qin, Fu-Ying1,2,3; Yan, Yong-Ming2; Tu, Zheng-Chao4; Cheng, Yong-Xian1,2,5
2018-09-01
发表期刊FITOTERAPIA
ISSN0367-326X
卷号129页码:167-172
摘要(+)- and (-)-Spirocochlealactones A-C (1-3), three pairs of new spiro meroterpenoidal dimeric enantiomers together with one known compound ganodilactone (4), were isolated from the fruiting bodies of Ganoderma cochlear. Their structures including absolute configurations were assigned by using spectroscopic methods and ECD calculations. All the isolated compounds were tested for their COX-2 inhibitory and cytotoxic activities toward human cancer lines (A549, K562, and Huh-7). The results show that all the compounds could inhibit COX-2 with IC50 values in the range of 1.29 to 3.63 mu M. In addition, (+)-spirocochlealactone A and (+)-ganodilactone were found to be moderate activities against human cancer cell line A549 with the IC50 values of 7.14 and 9.47 mu M, respectively.
关键词Ganoderma cochlear Meroterpenoids Computational methods Cytotoxicity COX-2
资助信息National Science Fund for Distinguished Young Scholars; National Key Research and Development Program of China; NSFC-Joint Foundation of Yunnan Province; National Natural Science Foundation of China
DOI10.1016/j.fitote.2018.06.019
语种英语
资助项目National Science Fund for Distinguished Young Scholars[81525026] ; National Key Research and Development Program of China[2017YFA0503900] ; NSFC-Joint Foundation of Yunnan Province[U1702287] ; National Natural Science Foundation of China[21472199]
WOS研究方向Pharmacology & Pharmacy
WOS类目Chemistry, Medicinal ; Pharmacology & Pharmacy
WOS记录号WOS:000443663800025
出版者ELSEVIER SCIENCE BV
引用统计
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/62299
专题植物化学与西部植物资源持续利用国家重点实验室
通讯作者Cheng, Yong-Xian
作者单位1.Henan Univ Chinese Med, Coll Pharm, Zhengzhou 450008, Henan, Peoples R China
2.Shenzhen Univ, Sch Pharmaceut Sci, Guangdong Key Lab Genome Stabil & Dis Prevent, Hlth Sci Ctr, Shenzhen 518060, Peoples R China
3.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
4.Chinese Acad Sci, Guangzhou Inst Biomed & Hlth, Guangzhou 510530, Guangdong, Peoples R China
5.Shenzhen Univ, Hlth Sci Ctr, Sch Pharmaceut Sci, Shenzhen 518060, Peoples R China
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Qin, Fu-Ying,Yan, Yong-Ming,Tu, Zheng-Chao,et al. Meroterpenoid dimers from Ganoderma cochlear and their cytotoxic and COX-2 inhibitory activities[J]. FITOTERAPIA,2018,129:167-172.
APA Qin, Fu-Ying,Yan, Yong-Ming,Tu, Zheng-Chao,&Cheng, Yong-Xian.(2018).Meroterpenoid dimers from Ganoderma cochlear and their cytotoxic and COX-2 inhibitory activities.FITOTERAPIA,129,167-172.
MLA Qin, Fu-Ying,et al."Meroterpenoid dimers from Ganoderma cochlear and their cytotoxic and COX-2 inhibitory activities".FITOTERAPIA 129(2018):167-172.
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