Divergent biosynthesis of indole alkaloids FR900452 and spiro-maremycins
Duan, Yingyi1; Liu, Yanyan1; Huang, Tao2; Zou, Yi3; Huang, Tingting1; Hu, Kaifeng2; Deng, Zixin1; Lin, Shuangjun1
2018-08-14
Source PublicationORGANIC & BIOMOLECULAR CHEMISTRY
ISSN1477-0520
Volume16Issue:30Pages:5446-5451
AbstractFR900452 and spirocyclic maremycins, including F and G components, are structurally related indole alkaloids, previously identified from different Streptomyces species. These alkaloids feature an indole diketopiperazine motif linked with a cyclopentenone moiety, but the linkage differs in FR900452 and the spirocyclic maremycins. Here, FR900452 and its two new analogues were identified from the fermentation broth of Streptomyces sp. B9173, the producer of maremycins. Gene inactivation and heterologous expression of the mar gene cluster confirmed that production of FR900452 shares the same biosynthetic machinery that produces maremycins. FR900452 was identified as the precursor of maremycin A/B by feeding studies. MarP, a SnoaL-like protein, was demonstrated to differentiate the biosynthesis of FR900452 from that of spiro-form maremycin G.
DOI10.1039/c8ob01181h
Language英语
Citation statistics
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/61682
Collection植物化学与西部植物资源持续利用国家重点实验室
Affiliation1.Shanghai Jiao Tong Univ, Sch Life Sci & Biotechnol, Joint Int Lab Metab & Dev Sci, State Key Lab Microbial Metab, Shanghai 200240, Peoples R China
2.Chinese Acad Sci, Kunming Inst Bot, Kunming, Yunnan, Peoples R China
3.Southwest Univ, Coll Pharmaceut Sci & Chinese Med, Chongqing, Peoples R China
Recommended Citation
GB/T 7714
Duan, Yingyi,Liu, Yanyan,Huang, Tao,et al. Divergent biosynthesis of indole alkaloids FR900452 and spiro-maremycins[J]. ORGANIC & BIOMOLECULAR CHEMISTRY,2018,16(30):5446-5451.
APA Duan, Yingyi.,Liu, Yanyan.,Huang, Tao.,Zou, Yi.,Huang, Tingting.,...&Lin, Shuangjun.(2018).Divergent biosynthesis of indole alkaloids FR900452 and spiro-maremycins.ORGANIC & BIOMOLECULAR CHEMISTRY,16(30),5446-5451.
MLA Duan, Yingyi,et al."Divergent biosynthesis of indole alkaloids FR900452 and spiro-maremycins".ORGANIC & BIOMOLECULAR CHEMISTRY 16.30(2018):5446-5451.
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