Divergent biosynthesis of indole alkaloids FR900452 and spiro-maremycins

doi:10.1039/c8ob01181h

	Divergent biosynthesis of indole alkaloids FR900452 and spiro-maremycins
	Duan, Yingyi 1; Liu, Yanyan 1; Huang, Tao 2; Zou, Yi 3; Huang, Tingting 1; Hu, Kaifeng2 ; Deng, Zixin 1; Lin, Shuangjun 1
	2018-08-14
发表期刊	ORGANIC & BIOMOLECULAR CHEMISTRY
ISSN	1477-0520
卷号	16 期号:30 页码:5446-5451
摘要	FR900452 and spirocyclic maremycins, including F and G components, are structurally related indole alkaloids, previously identified from different Streptomyces species. These alkaloids feature an indole diketopiperazine motif linked with a cyclopentenone moiety, but the linkage differs in FR900452 and the spirocyclic maremycins. Here, FR900452 and its two new analogues were identified from the fermentation broth of Streptomyces sp. B9173, the producer of maremycins. Gene inactivation and heterologous expression of the mar gene cluster confirmed that production of FR900452 shares the same biosynthetic machinery that produces maremycins. FR900452 was identified as the precursor of maremycin A/B by feeding studies. MarP, a SnoaL-like protein, was demonstrated to differentiate the biosynthesis of FR900452 from that of spiro-form maremycin G.
DOI	10.1039/c8ob01181h
语种	英语
引用统计	被引频次：16[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/61682
专题	植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Shanghai Jiao Tong Univ, Sch Life Sci & Biotechnol, Joint Int Lab Metab & Dev Sci, State Key Lab Microbial Metab, Shanghai 200240, Peoples R China 2.Chinese Acad Sci, Kunming Inst Bot, Kunming, Yunnan, Peoples R China 3.Southwest Univ, Coll Pharmaceut Sci & Chinese Med, Chongqing, Peoples R China
推荐引用方式 GB/T 7714	Duan, Yingyi,Liu, Yanyan,Huang, Tao,et al. Divergent biosynthesis of indole alkaloids FR900452 and spiro-maremycins[J]. ORGANIC & BIOMOLECULAR CHEMISTRY,2018,16(30):5446-5451.
APA	Duan, Yingyi.,Liu, Yanyan.,Huang, Tao.,Zou, Yi.,Huang, Tingting.,...&Lin, Shuangjun.(2018).Divergent biosynthesis of indole alkaloids FR900452 and spiro-maremycins.ORGANIC & BIOMOLECULAR CHEMISTRY,16(30),5446-5451.
MLA	Duan, Yingyi,et al."Divergent biosynthesis of indole alkaloids FR900452 and spiro-maremycins".ORGANIC & BIOMOLECULAR CHEMISTRY 16.30(2018):5446-5451.