Liquid chromatography-mass spectrometry combined with xanthine oxidase inhibition profiling for identifying the bioactive constituents from Cistanche deserticola
Chen, Xinglong1,2; Deng, Zhentao1,2; Huang, Xiaoyan1,2; Geng, Changan1,2; Chen, Jijun1,2
2018-07-01
发表期刊INTERNATIONAL JOURNAL OF MASS SPECTROMETRY
ISSN1387-3806
卷号430页码:1-7
摘要Xanthine oxidase (XO) inhibitor can block the synthesis of uric acid and is regarded as one of the therapeutic approaches of gout. The anti-XO constituents in the stem of Cistanche deserticola were characterized though LC-MS combined with xanthine oxidase inhibition profiling method. Seven phenylethanoid glycosides (1-7) and two phenylpropanoid glycosides (8-9) were identified from the bioactive extracts. Isoacteoside (1), kankanoside G (4) and cistanoside F (8) displayed crucial activity against XO with the IC50 values of 46.91, 85.31 mu M and 36.41 mu M respectively. The main mass fragmentation pathways of phenylethanoid glycosides were the losses of glucosyl, rhamanopyranosyl and phenylethoxyl groups in positive ion mode and the elimination of caffeoyl unit in negative ion mode. It shows that the stem of Cistanche deserticola is a functional food which performs potent anti-gout activity. (C) 2018 Elsevier B.V. All rights reserved.
关键词Lc-ms Xanthine Oxidase Inhibitor Anti-gout Mass Fragmentation Pathway Cistanche Deserticola
语种英语
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文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/61386
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, 132 Lanhei Rd, Kunming 650201, Yunnan, Peoples R China
2.Yunnan Key Lab Nat Med Chem, Kunming 650201, Yunnan, Peoples R China
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Chen, Xinglong,Deng, Zhentao,Huang, Xiaoyan,et al. Liquid chromatography-mass spectrometry combined with xanthine oxidase inhibition profiling for identifying the bioactive constituents from Cistanche deserticola[J]. INTERNATIONAL JOURNAL OF MASS SPECTROMETRY,2018,430:1-7.
APA Chen, Xinglong,Deng, Zhentao,Huang, Xiaoyan,Geng, Changan,&Chen, Jijun.(2018).Liquid chromatography-mass spectrometry combined with xanthine oxidase inhibition profiling for identifying the bioactive constituents from Cistanche deserticola.INTERNATIONAL JOURNAL OF MASS SPECTROMETRY,430,1-7.
MLA Chen, Xinglong,et al."Liquid chromatography-mass spectrometry combined with xanthine oxidase inhibition profiling for identifying the bioactive constituents from Cistanche deserticola".INTERNATIONAL JOURNAL OF MASS SPECTROMETRY 430(2018):1-7.
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