Liquid chromatography-mass spectrometry combined with xanthine oxidase inhibition profiling for identifying the bioactive constituents from Cistanche deserticola
Chen, Xinglong1,2; Deng, Zhentao1,2; Huang, Xiaoyan1,2; Geng, Changan1,2; Chen, Jijun1,2
2018-07-01
Source PublicationINTERNATIONAL JOURNAL OF MASS SPECTROMETRY
ISSN1387-3806
Volume430Pages:1-7
AbstractXanthine oxidase (XO) inhibitor can block the synthesis of uric acid and is regarded as one of the therapeutic approaches of gout. The anti-XO constituents in the stem of Cistanche deserticola were characterized though LC-MS combined with xanthine oxidase inhibition profiling method. Seven phenylethanoid glycosides (1-7) and two phenylpropanoid glycosides (8-9) were identified from the bioactive extracts. Isoacteoside (1), kankanoside G (4) and cistanoside F (8) displayed crucial activity against XO with the IC50 values of 46.91, 85.31 mu M and 36.41 mu M respectively. The main mass fragmentation pathways of phenylethanoid glycosides were the losses of glucosyl, rhamanopyranosyl and phenylethoxyl groups in positive ion mode and the elimination of caffeoyl unit in negative ion mode. It shows that the stem of Cistanche deserticola is a functional food which performs potent anti-gout activity. (C) 2018 Elsevier B.V. All rights reserved.
KeywordLc-ms Xanthine Oxidase Inhibitor Anti-gout Mass Fragmentation Pathway Cistanche Deserticola
DOI10.1016/j.ijms.2018.03.009
Language英语
Citation statistics
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/61386
Collection植物化学与西部植物资源持续利用国家重点实验室
Affiliation1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, 132 Lanhei Rd, Kunming 650201, Yunnan, Peoples R China
2.Yunnan Key Lab Nat Med Chem, Kunming 650201, Yunnan, Peoples R China
Recommended Citation
GB/T 7714
Chen, Xinglong,Deng, Zhentao,Huang, Xiaoyan,et al. Liquid chromatography-mass spectrometry combined with xanthine oxidase inhibition profiling for identifying the bioactive constituents from Cistanche deserticola[J]. INTERNATIONAL JOURNAL OF MASS SPECTROMETRY,2018,430:1-7.
APA Chen, Xinglong,Deng, Zhentao,Huang, Xiaoyan,Geng, Changan,&Chen, Jijun.(2018).Liquid chromatography-mass spectrometry combined with xanthine oxidase inhibition profiling for identifying the bioactive constituents from Cistanche deserticola.INTERNATIONAL JOURNAL OF MASS SPECTROMETRY,430,1-7.
MLA Chen, Xinglong,et al."Liquid chromatography-mass spectrometry combined with xanthine oxidase inhibition profiling for identifying the bioactive constituents from Cistanche deserticola".INTERNATIONAL JOURNAL OF MASS SPECTROMETRY 430(2018):1-7.
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Chen, Xinglong]'s Articles
[Deng, Zhentao]'s Articles
[Huang, Xiaoyan]'s Articles
Baidu academic
Similar articles in Baidu academic
[Chen, Xinglong]'s Articles
[Deng, Zhentao]'s Articles
[Huang, Xiaoyan]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Chen, Xinglong]'s Articles
[Deng, Zhentao]'s Articles
[Huang, Xiaoyan]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.