Cirsitakaoside isolated from Prenma szemaoensis reduces LPS-induced inflammatory responses in vitro and in vivo
Zhu, Huihui1,3; Pu, Debing2,4; Di, Qianqian1; Zhao, Xibao1,3; Ji, Feiyang3; Li, Hongrui1,3; Zhao, Zizhao3; Gao, Junbo4; Xiao, Weilie2,4; Chen, Weilin1,3
2018-06-01
Source PublicationINTERNATIONAL IMMUNOPHARMACOLOGY
ISSN1567-5769
Volume59Pages:384-390
AbstractCirsitakaoside is a natural compound isolated from Prettuta szemaoensis. However, the anti-inflammatory effects of cirsitakaoside are poorly understood. We investigated the anti-inflammatory action of cirsitakaoside in lipopolysaccharide (LPS)-stimulated macrophages and mice in vivo. Cirsitakaoside could suppress the production of pro-inflammatory cytokines such as interleukin-1 beta (IL-1 beta) interleukin-6 (IL-6) and tumor necrosis factor alpha (TNF-alpha) in a dose-dependent manner in LPS-stimulated mouse peritoneal macrophages and RAW264.7 cells. Cirsitakaoside also could inhibit inducible nitric oxide synthase (iNOS) mRNA and cyclooxygenase-2 (COX 2) mRNA expression in LPS-stimulated mouse peritoneal macrophages and RAW264.7 cells. These effects were partially carried out by inactivated nuclear factor-kappa B (NF-kappa B) and Mitogen-activated protein kinases (MAPKs) pathway via inhibiting the phosphorylation of the IKK alpha/beta, I kappa B alpha and c-Jun N-terminal kinase/stress-activated protein kinase (JNK) in LPS-stimulated murine macrophages. In vivo, we showed that cirsitakaoside could relieve LPS-induced inflammation response. These results suggest that cirsitakaoside has the potential anti-inflammatory effect for treatment of inflammation diseases.
KeywordCirsitakaoside Lps Inflammation Macrophage Nf-kappa b
DOI10.1016/j.intimp.2018.04.030
Language英语
Citation statistics
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/61385
Collection植物化学与西部植物资源持续利用国家重点实验室
Affiliation1.Shenzhen Univ, Sch Med, Dept Immunol, Shenzhen 518060, Peoples R China
2.Yunnan Univ, Sch Chem Sci & Technol, Key Lab Med Chem Nat Resource, Minist Educ & Yunnan Prov, Kunming 650091, Yunnan, Peoples R China
3.Zhejiang Univ, Inst Immunol, Sch Med, Hangzhou 310058, Zhejiang, Peoples R China
4.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West C, Kunming 650201, Yunnan, Peoples R China
Recommended Citation
GB/T 7714
Zhu, Huihui,Pu, Debing,Di, Qianqian,et al. Cirsitakaoside isolated from Prenma szemaoensis reduces LPS-induced inflammatory responses in vitro and in vivo[J]. INTERNATIONAL IMMUNOPHARMACOLOGY,2018,59:384-390.
APA Zhu, Huihui.,Pu, Debing.,Di, Qianqian.,Zhao, Xibao.,Ji, Feiyang.,...&Chen, Weilin.(2018).Cirsitakaoside isolated from Prenma szemaoensis reduces LPS-induced inflammatory responses in vitro and in vivo.INTERNATIONAL IMMUNOPHARMACOLOGY,59,384-390.
MLA Zhu, Huihui,et al."Cirsitakaoside isolated from Prenma szemaoensis reduces LPS-induced inflammatory responses in vitro and in vivo".INTERNATIONAL IMMUNOPHARMACOLOGY 59(2018):384-390.
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