Three New Polyynes from Codonopsis pilosula and Their Activities on Lipid Metabolism
Hu, Xiao-Yu1,2; Qin, Fu-Ying2,3; Lu, Xi-Feng2; Zhang, Lan-Sheng1; Cheng, Yong-Xian2,4,5
2018-04-01
Source PublicationMOLECULES
ISSN1420-3049
Volume23Issue:4Pages:887
AbstractThree new polyynes, named choushenpilosulynes A-C (1-3), were isolated from an 85% aqueous EtOH extract of the roots of Codonopsis pilosula cultivated in Xundian County of Yunnan province, China. Their structures, including the absolute configuration of the glucose residue in 1 and 2, were determined by spectroscopic analysis and gas chromatography (GC). In addition, biological evaluation shows that all the compounds can inhibit the expression of the squalene monooxygenase (SQLE) gene in HepG2 cells, suggesting that these compounds may be involved in lipid metabolism.
KeywordCodonopsis Pilosula Choushenpilosulynes A-c Lipid Metabolism
DOI10.3390/molecules23040887
Language英语
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Cited Times:2[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/61372
Collection植物化学与西部植物资源持续利用国家重点实验室
Affiliation1.Dali Univ, Sch Pharm & Chem, Dali 671000, Peoples R China
2.Shenzhen Univ, Sch Pharmaceut Sci, Guangdong Key Lab Genome Stabil & Dis Prevent, Hlth Sci Ctr,Sch Med, Shenzhen 518060, Peoples R China
3.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
4.Henan Univ Chinese Med, Sch Pharm, Zhengzhou 450008, Henan, Peoples R China
5.Chengdu Univ Tradit Chinese Med, Coll Pharm, Chengdu 610075, Sichuan, Peoples R China
Recommended Citation
GB/T 7714
Hu, Xiao-Yu,Qin, Fu-Ying,Lu, Xi-Feng,et al. Three New Polyynes from Codonopsis pilosula and Their Activities on Lipid Metabolism[J]. MOLECULES,2018,23(4):887.
APA Hu, Xiao-Yu,Qin, Fu-Ying,Lu, Xi-Feng,Zhang, Lan-Sheng,&Cheng, Yong-Xian.(2018).Three New Polyynes from Codonopsis pilosula and Their Activities on Lipid Metabolism.MOLECULES,23(4),887.
MLA Hu, Xiao-Yu,et al."Three New Polyynes from Codonopsis pilosula and Their Activities on Lipid Metabolism".MOLECULES 23.4(2018):887.
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