| Three New Polyynes from Codonopsis pilosula and Their Activities on Lipid Metabolism | |
| Hu, Xiao-Yu1,2; Qin, Fu-Ying2,3; Lu, Xi-Feng2; Zhang, Lan-Sheng1; Cheng, Yong-Xian2,4,5 | |
| 2018-04-01 | |
| 发表期刊 | MOLECULES
 |
| ISSN | 1420-3049 |
| 卷号 | 23期号:4页码:887 |
| 摘要 | Three new polyynes, named choushenpilosulynes A-C (1-3), were isolated from an 85% aqueous EtOH extract of the roots of Codonopsis pilosula cultivated in Xundian County of Yunnan province, China. Their structures, including the absolute configuration of the glucose residue in 1 and 2, were determined by spectroscopic analysis and gas chromatography (GC). In addition, biological evaluation shows that all the compounds can inhibit the expression of the squalene monooxygenase (SQLE) gene in HepG2 cells, suggesting that these compounds may be involved in lipid metabolism. |
| 关键词 | Codonopsis Pilosula Choushenpilosulynes A-c Lipid Metabolism |
| DOI | 10.3390/molecules23040887 |
| 语种 | 英语 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kib.ac.cn/handle/151853/61372 |
| 专题 | 植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Dali Univ, Sch Pharm & Chem, Dali 671000, Peoples R China 2.Shenzhen Univ, Sch Pharmaceut Sci, Guangdong Key Lab Genome Stabil & Dis Prevent, Hlth Sci Ctr,Sch Med, Shenzhen 518060, Peoples R China 3.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 4.Henan Univ Chinese Med, Sch Pharm, Zhengzhou 450008, Henan, Peoples R China 5.Chengdu Univ Tradit Chinese Med, Coll Pharm, Chengdu 610075, Sichuan, Peoples R China |
| 推荐引用方式 GB/T 7714 | Hu, Xiao-Yu,Qin, Fu-Ying,Lu, Xi-Feng,et al. Three New Polyynes from Codonopsis pilosula and Their Activities on Lipid Metabolism[J]. MOLECULES,2018,23(4):887. |
| APA | Hu, Xiao-Yu,Qin, Fu-Ying,Lu, Xi-Feng,Zhang, Lan-Sheng,&Cheng, Yong-Xian.(2018).Three New Polyynes from Codonopsis pilosula and Their Activities on Lipid Metabolism.MOLECULES,23(4),887. |
| MLA | Hu, Xiao-Yu,et al."Three New Polyynes from Codonopsis pilosula and Their Activities on Lipid Metabolism".MOLECULES 23.4(2018):887. |
| 条目包含的文件 | 条目无相关文件。 | |||||
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