An anticoagulant fucan sulfate with hexasaccharide repeating units from the sea cucumber Holothuria albiventer
Cai, Ying1,2; Yang, Wenjiao1,2; Yin, Ronghua1,2; Zhou, Lutan1; Li, Zhongkun3; Wu, Mingyi1; Zhao, Jinhua1
2018-07-15
发表期刊CARBOHYDRATE RESEARCH
ISSN0008-6215
卷号464页码:12-18
摘要A fucan sulfate was isolated and purified from the sea cucumber Holothuria albiventer by papain enzymolysis, alkaline hydrolysis and ion-exchange chromatography. The water-soluble polysaccharide had high molecular weight and contained fucose and sulfate in a molar ratio of about 1:0.83. Methylation analysis of the native polysaccharide indicated that its glycosidic linkages and sulfate substituents might be at O-3 or O-3, 4 or O-2, 3, or O-2, 3, 4 positions. FT-IR and 2D NMR spectroscopies further revealed that the fucan sulfate is characteristically composed of a regular a (1 -> 3) linked hexasaccharide repeating unit which is substituted with sulfate esters in a distinctive pattern. Anticoagulant properties of the fucan sulfate and its depolymerized product were assessed in vitro in comparison with a low-molecular-weight heparin. The fucan sulfate exhibits strong APTT and TT prolonging activities and intrinsic factor Xase inhibitory activity, and its molecular size seemed to be required for these activities.
关键词Fucan Sulfate Chemical Structure Anticoagulant Polysaccharide Sea Cucumber
DOI10.1016/j.carres.2018.05.007
语种英语
引用统计
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/61368
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.Kunming Med Univ, Dept Pharm, Yanan Hosp, Kunming 650051, Yunnan, Peoples R China
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Cai, Ying,Yang, Wenjiao,Yin, Ronghua,et al. An anticoagulant fucan sulfate with hexasaccharide repeating units from the sea cucumber Holothuria albiventer[J]. CARBOHYDRATE RESEARCH,2018,464:12-18.
APA Cai, Ying.,Yang, Wenjiao.,Yin, Ronghua.,Zhou, Lutan.,Li, Zhongkun.,...&Zhao, Jinhua.(2018).An anticoagulant fucan sulfate with hexasaccharide repeating units from the sea cucumber Holothuria albiventer.CARBOHYDRATE RESEARCH,464,12-18.
MLA Cai, Ying,et al."An anticoagulant fucan sulfate with hexasaccharide repeating units from the sea cucumber Holothuria albiventer".CARBOHYDRATE RESEARCH 464(2018):12-18.
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