C21 steroidal glycosides with cytotoxic activities from Cynanchum otophyllum
Dong, Jinrun1,2,3; Peng, Xingrong1,3; Li, Lei1,2,3; Lu, Shuangyang1,2,3; Zhou, Lin1,3; Qiu, Minghua1,3
2018-05-15
Source PublicationBIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN0960-894X
Volume28Issue:9Pages:1520-1524
Abstract

Eight new C21 steroidal glycosides, namely cynanotins A-H (1-8), together with fifteen known analogues, were isolated from the roots of Cynanchum otophyllum. Their structures were elucidated by spectroscopic analysis and chemical methods. In this study, all of isolates were tested for their vitro inhibitory activities against five human tumor cell lines (HL-60, SMMC-7721, A-549, MCF-7 and SW480). Compounds 3-15 showed moderate cytotoxic activities against HL-60 cell lines with IC50 values ranging from 11.4 to 37.9 mu M. Compounds 5, 9, and 10 showed marked or moderate cytotoxic activities against five human tumor cell lines with IC50 values ranging from 11.4 to 36.7 mu M. Compound 11 displayed moderate cytotoxic activities against HL-60, SMMC-7721, MCF-7 and SW480 cell lines with IC50 values of 12.2-30.8 mu M. Compared to the positive control (IC50: 35.0 mu M), compounds 5, 9-11 exhibited more potential inhibitory activity against MCF-7 cells (IC50: 16.1-25.6 mu M). (C) 2018 Published by Elsevier Ltd.

KeywordAsclepiadaceae Cynanchum Otophyllum C21 Steroidal Glycosides Cytotoxicities
DOI10.1016/j.bmcl.2018.03.078
Language英语
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Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/61366
Collection植物化学与西部植物资源持续利用国家重点实验室
Affiliation1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming, Yunnan, Peoples R China
2.Univ Chinese Acad Sci, Beijing, Peoples R China
3.Chinese Acad Sci, Kunming Inst Bot, Yunnan Key Lab Nat Med Chem, Kunming 650201, Yunnan, Peoples R China
Recommended Citation
GB/T 7714
Dong, Jinrun,Peng, Xingrong,Li, Lei,et al. C21 steroidal glycosides with cytotoxic activities from Cynanchum otophyllum[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2018,28(9):1520-1524.
APA Dong, Jinrun,Peng, Xingrong,Li, Lei,Lu, Shuangyang,Zhou, Lin,&Qiu, Minghua.(2018).C21 steroidal glycosides with cytotoxic activities from Cynanchum otophyllum.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,28(9),1520-1524.
MLA Dong, Jinrun,et al."C21 steroidal glycosides with cytotoxic activities from Cynanchum otophyllum".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 28.9(2018):1520-1524.
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