Antibacterial Dimeric Acylphloroglucinols from Hypericum japonicum
Li, Yan-Ping; Hu, Kun; Yang, Xing-Wei1; Xu, Gang1
2018-04-01
发表期刊JOURNAL OF NATURAL PRODUCTS
ISSN0163-3864
卷号81期号:4页码:1098-1102
摘要

Nine dimeric acylphloroglucinols, including the new hyperjaponicols A-D (1-4), were isolated from the whole plant of Hypericum japonicum. The new structures were determined by the interpretation of NMR and MS data, and the relative configuration of the known compound, sarothralen C (5), was reassigned via NMR spectroscopic analysis and single-crystal X-ray diffraction data. The inhibitory activities of the isolates against four bacterial strains were evaluated, and compounds 1-4, 6, and 7 exhibited significant antibacterial activity with MIC values of 0.8-3.4 mu M. In addition, compound 3 showed moderate lipase inhibitory activity (IC50 8.3 mu M).

语种英语
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文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/61363
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
2.Yunnan Key Lab Nat Med Chem, Kunming 650201, Yunnan, Peoples R China
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Li, Yan-Ping,Hu, Kun,Yang, Xing-Wei,et al. Antibacterial Dimeric Acylphloroglucinols from Hypericum japonicum[J]. JOURNAL OF NATURAL PRODUCTS,2018,81(4):1098-1102.
APA Li, Yan-Ping,Hu, Kun,Yang, Xing-Wei,&Xu, Gang.(2018).Antibacterial Dimeric Acylphloroglucinols from Hypericum japonicum.JOURNAL OF NATURAL PRODUCTS,81(4),1098-1102.
MLA Li, Yan-Ping,et al."Antibacterial Dimeric Acylphloroglucinols from Hypericum japonicum".JOURNAL OF NATURAL PRODUCTS 81.4(2018):1098-1102.
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