Antibacterial Dimeric Acylphloroglucinols from Hypericum japonicum
Li, Yan-Ping; Hu, Kun; Yang, Xing-Wei1; Xu, Gang1
2018-04-01
Source PublicationJOURNAL OF NATURAL PRODUCTS
ISSN0163-3864
Volume81Issue:4Pages:1098-1102
Abstract

Nine dimeric acylphloroglucinols, including the new hyperjaponicols A-D (1-4), were isolated from the whole plant of Hypericum japonicum. The new structures were determined by the interpretation of NMR and MS data, and the relative configuration of the known compound, sarothralen C (5), was reassigned via NMR spectroscopic analysis and single-crystal X-ray diffraction data. The inhibitory activities of the isolates against four bacterial strains were evaluated, and compounds 1-4, 6, and 7 exhibited significant antibacterial activity with MIC values of 0.8-3.4 mu M. In addition, compound 3 showed moderate lipase inhibitory activity (IC50 8.3 mu M).

DOI10.1021/acs.jnatprod.8b00017
Language英语
Citation statistics
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/61363
Collection植物化学与西部植物资源持续利用国家重点实验室
Affiliation1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
2.Yunnan Key Lab Nat Med Chem, Kunming 650201, Yunnan, Peoples R China
Recommended Citation
GB/T 7714
Li, Yan-Ping,Hu, Kun,Yang, Xing-Wei,et al. Antibacterial Dimeric Acylphloroglucinols from Hypericum japonicum[J]. JOURNAL OF NATURAL PRODUCTS,2018,81(4):1098-1102.
APA Li, Yan-Ping,Hu, Kun,Yang, Xing-Wei,&Xu, Gang.(2018).Antibacterial Dimeric Acylphloroglucinols from Hypericum japonicum.JOURNAL OF NATURAL PRODUCTS,81(4),1098-1102.
MLA Li, Yan-Ping,et al."Antibacterial Dimeric Acylphloroglucinols from Hypericum japonicum".JOURNAL OF NATURAL PRODUCTS 81.4(2018):1098-1102.
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