Identification of Ingol and Rhamnofolane Diterpenoids from Euphorbia resinifera and Their Abilities to Induce Lysosomal Biosynthesis
Zhao, Ning-Dong1,2,3; Ding, Xiao2; Song, Yu2; Yang, Dong-Qiong2; Adelakun, Tiwalade Adegoke2; Qian, Wen-Dan2; Zhang, Yu2; Di, Ying-Tong2; Gao, Fang1; Hao, Xiao-Jiang2; Li, Shun-Lin2
2018-05-01
Source PublicationJOURNAL OF NATURAL PRODUCTS
ISSN0163-3864
Volume81Issue:5Pages:1209-1218
AbstractThe phytochemical study of Euphorbia resinifera afforded 18 structurally diverse diterpenoids, including 14 new ingol-type diterpenoids, euphorblins A-N (1-14), a new rhamnofolane diterpenoid, euphorblin 0 (Is), and three known analogues (16-18). The structures of these compounds were deduced using 2D NMR spectroscopy and NOE experiments. The structure of compound 1 was confirmed by single-crystal X-ray crystallography. The abilities of the compounds to enhance lysosomal biosynthesis were evaluated through LysoTracker Red staining. Among the 10 active compounds, compounds 2, 4, and 18 showed remarkable immunofluorescence strength, and their LysoTracker staining intensities were 155.9%, 143.5%, and 140.7%, respectively, greater than that of the control. A series of lysosomal genes were also found to be upregulated by these compounds, which further confirms their ability to induce lysosome biosynthesis and suggests that these diterpenoids have potential as lead compounds for the development of drugs for the treatment of lysosome-related diseases.
DOI10.1021/acs.jnatprod.7b00981
Language英语
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Cited Times:3[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/61346
Collection植物化学与西部植物资源持续利用国家重点实验室
Affiliation1.Chongqing Univ, Coll Chem & Chem Engn, Chongqing 400044, Peoples R China
2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
3.Wenshan Univ, Coll Chem & Engn, Wenshan 663000, Peoples R China
Recommended Citation
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Zhao, Ning-Dong,Ding, Xiao,Song, Yu,et al. Identification of Ingol and Rhamnofolane Diterpenoids from Euphorbia resinifera and Their Abilities to Induce Lysosomal Biosynthesis[J]. JOURNAL OF NATURAL PRODUCTS,2018,81(5):1209-1218.
APA Zhao, Ning-Dong.,Ding, Xiao.,Song, Yu.,Yang, Dong-Qiong.,Adelakun, Tiwalade Adegoke.,...&Li, Shun-Lin.(2018).Identification of Ingol and Rhamnofolane Diterpenoids from Euphorbia resinifera and Their Abilities to Induce Lysosomal Biosynthesis.JOURNAL OF NATURAL PRODUCTS,81(5),1209-1218.
MLA Zhao, Ning-Dong,et al."Identification of Ingol and Rhamnofolane Diterpenoids from Euphorbia resinifera and Their Abilities to Induce Lysosomal Biosynthesis".JOURNAL OF NATURAL PRODUCTS 81.5(2018):1209-1218.
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