Identification of Ingol and Rhamnofolane Diterpenoids from Euphorbia resinifera and Their Abilities to Induce Lysosomal Biosynthesis
Zhao, Ning-Dong1,2,3; Ding, Xiao2; Song, Yu2; Yang, Dong-Qiong2; Adelakun, Tiwalade Adegoke2; Qian, Wen-Dan2; Zhang, Yu2; Di, Ying-Tong2; Gao, Fang1; Hao, Xiao-Jiang2; Li, Shun-Lin2
2018-05-01
发表期刊JOURNAL OF NATURAL PRODUCTS
ISSN0163-3864
卷号81期号:5页码:1209-1218
摘要The phytochemical study of Euphorbia resinifera afforded 18 structurally diverse diterpenoids, including 14 new ingol-type diterpenoids, euphorblins A-N (1-14), a new rhamnofolane diterpenoid, euphorblin 0 (Is), and three known analogues (16-18). The structures of these compounds were deduced using 2D NMR spectroscopy and NOE experiments. The structure of compound 1 was confirmed by single-crystal X-ray crystallography. The abilities of the compounds to enhance lysosomal biosynthesis were evaluated through LysoTracker Red staining. Among the 10 active compounds, compounds 2, 4, and 18 showed remarkable immunofluorescence strength, and their LysoTracker staining intensities were 155.9%, 143.5%, and 140.7%, respectively, greater than that of the control. A series of lysosomal genes were also found to be upregulated by these compounds, which further confirms their ability to induce lysosome biosynthesis and suggests that these diterpenoids have potential as lead compounds for the development of drugs for the treatment of lysosome-related diseases.
语种英语
引用统计
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/61346
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Chongqing Univ, Coll Chem & Chem Engn, Chongqing 400044, Peoples R China
2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
3.Wenshan Univ, Coll Chem & Engn, Wenshan 663000, Peoples R China
推荐引用方式
GB/T 7714
Zhao, Ning-Dong,Ding, Xiao,Song, Yu,et al. Identification of Ingol and Rhamnofolane Diterpenoids from Euphorbia resinifera and Their Abilities to Induce Lysosomal Biosynthesis[J]. JOURNAL OF NATURAL PRODUCTS,2018,81(5):1209-1218.
APA Zhao, Ning-Dong.,Ding, Xiao.,Song, Yu.,Yang, Dong-Qiong.,Adelakun, Tiwalade Adegoke.,...&Li, Shun-Lin.(2018).Identification of Ingol and Rhamnofolane Diterpenoids from Euphorbia resinifera and Their Abilities to Induce Lysosomal Biosynthesis.JOURNAL OF NATURAL PRODUCTS,81(5),1209-1218.
MLA Zhao, Ning-Dong,et al."Identification of Ingol and Rhamnofolane Diterpenoids from Euphorbia resinifera and Their Abilities to Induce Lysosomal Biosynthesis".JOURNAL OF NATURAL PRODUCTS 81.5(2018):1209-1218.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Zhao, Ning-Dong]的文章
[Ding, Xiao]的文章
[Song, Yu]的文章
百度学术
百度学术中相似的文章
[Zhao, Ning-Dong]的文章
[Ding, Xiao]的文章
[Song, Yu]的文章
必应学术
必应学术中相似的文章
[Zhao, Ning-Dong]的文章
[Ding, Xiao]的文章
[Song, Yu]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。