Vibsane-Type Diterpenoids from Viburnum odoratissimum and Their Cytotoxic and HSP90 Inhibitory Activities

doi:10.1002/cbdv.201800049

	Vibsane-Type Diterpenoids from Viburnum odoratissimum and Their Cytotoxic and HSP90 Inhibitory Activities
	Zhu, Qin-Feng 1,2; Qi, Yan-Yan 1,2; Zhang, Zhi-Jun 1,2; Fan, Min1,2 ; Bi, Ran 1,2; Su, Jia 1; Wu, Xing-De 1; Shao, Li-Dong 1; Zhao, Qin-Shi1
	2018-05-01
发表期刊	CHEMISTRY & BIODIVERSITY
ISSN	1612-1872
卷号	15 期号:5 页码:1800049
摘要	Four new vibsane-type diterpenoids, vibsanol I (1), 15-hydroperoxyvibsanol A (2), 14-hydroperoxyvibsanol B (3), 15-O-methylvibsanin U (4), and a new natural product, 5,6-dihydrovibsanin B (5), as well as six known analogues, were isolated from the twigs and leaves of Viburnum odoratissimum. Their structures were elucidated by spectroscopic analyses and chemical derivatization method. All compounds showed different levels of cytotoxicity against five cell lines (HL-60, A-549, SMMC-7721, MCF-7, and SW480). Remarkably, 14,18-O-diacetyl-15-O-methylvibsanin U (4a) showed significant cytotoxicity against HL-60, A-549, SMMC-7721, MCF-7, and SW480, with IC50 values of 0.15 +/- 0.01, 0.69 +/- 0.01, 0.41 +/- 0.02, 0.75 +/- 0.03, and 0.48 +/- 0.03m, respectively. In addition, vibsanin K (10) was identified as a HSP90 inhibitor with an IC50 value of 19.16m.
关键词	Vibsane-type Diterpenoids Viburnum Odoratissimum Cytotoxicity Hsp90 Inhibitor
DOI	10.1002/cbdv.201800049
语种	英语
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/61333
专题	植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Zhu, Qin-Feng,Qi, Yan-Yan,Zhang, Zhi-Jun,et al. Vibsane-Type Diterpenoids from Viburnum odoratissimum and Their Cytotoxic and HSP90 Inhibitory Activities[J]. CHEMISTRY & BIODIVERSITY,2018,15(5):1800049.
APA	Zhu, Qin-Feng.,Qi, Yan-Yan.,Zhang, Zhi-Jun.,Fan, Min.,Bi, Ran.,...&Zhao, Qin-Shi.(2018).Vibsane-Type Diterpenoids from Viburnum odoratissimum and Their Cytotoxic and HSP90 Inhibitory Activities.CHEMISTRY & BIODIVERSITY,15(5),1800049.
MLA	Zhu, Qin-Feng,et al."Vibsane-Type Diterpenoids from Viburnum odoratissimum and Their Cytotoxic and HSP90 Inhibitory Activities".CHEMISTRY & BIODIVERSITY 15.5(2018):1800049.