Cochlearoids L and M: Two New Meroterpenoids from the Fungus Ganoderma cochlear | |
Qin, Fu-Ying1,2; Yan, Yong-Ming3; Tu, Zheng-Chao4; Cheng, Yong-Xian1,2,3 | |
2018-03-01 | |
发表期刊 | NATURAL PRODUCT COMMUNICATIONS |
ISSN | 1934-578X |
卷号 | 13期号:3页码:303-305 |
摘要 | Cochlearoids L (1) and M (2), two new meroterpenoids and three known ones, were isolated from the fruiting bodies of Ganoderma cochlear. The new structures were elucidated by spectroscopic and chemical methods. Biological evaluation showed that 1 could inhibit bromodomain-containing protein 4 (BRD4) with IC50 value of 68.7 mu M. Besides, 1 was found to have weak cytotoxic activities against three human cell lines (A549, K562, Huh-7) with IC50 values in the range of 39.6-190.0 mu M. |
关键词 | Ganoderma Cochlear Brd4 Cytotoxic Meroterpenoids |
语种 | 英语 |
文献类型 | 期刊论文 |
条目标识符 | http://ir.kib.ac.cn/handle/151853/61331 |
专题 | 植物化学与西部植物资源持续利用国家重点实验室 |
作者单位 | 1.Henan Univ Chinese Med, Zhengzhou 450008, Henan, Peoples R China 2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 3.Shenzhen Univ, Hlth Sci Ctr, Sch Pharmaceut Sci, Shenzhen 518060, Peoples R China 4.Chinese Acad Sci, Guangzhou Inst Biomed & Hlth, Guangzhou 510530, Guangdong, Peoples R China |
推荐引用方式 GB/T 7714 | Qin, Fu-Ying,Yan, Yong-Ming,Tu, Zheng-Chao,et al. Cochlearoids L and M: Two New Meroterpenoids from the Fungus Ganoderma cochlear[J]. NATURAL PRODUCT COMMUNICATIONS,2018,13(3):303-305. |
APA | Qin, Fu-Ying,Yan, Yong-Ming,Tu, Zheng-Chao,&Cheng, Yong-Xian.(2018).Cochlearoids L and M: Two New Meroterpenoids from the Fungus Ganoderma cochlear.NATURAL PRODUCT COMMUNICATIONS,13(3),303-305. |
MLA | Qin, Fu-Ying,et al."Cochlearoids L and M: Two New Meroterpenoids from the Fungus Ganoderma cochlear".NATURAL PRODUCT COMMUNICATIONS 13.3(2018):303-305. |
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