PPAR alpha Mediates the Hepatoprotective Effects of Nutmeg
Yang, Xiao-Nan1; Liu, Xue-Mei1,2; Fang, Jian-He3; Zhu, Xu1; Yang, Xiu-Wei4; Xiao, Xue-Rong1; Huang, Jian-Feng1; Gonzalez, Frank J.5; Li, Fei1,6
AbstractNutmeg is a Traditional Chinese Medicine used to treat gastrointestinal diseases. Some reports have indicated that nutmeg has hepatoprotective activity. In this study, a thioacetamide (TAA)-induced acute liver injury model in mice was used to explore the mechanism of the protective effects of nutmeg extract (NME), including its major bioactive component myrislignan. The results indicated that NME could effectively protect TAA-induced liver damage as assessed by recovery of increased serumtransaminases, decrease in hepatic oxidative stress, and lower hepatic inflammation. Metabolomics analysis further revealed that treatment with NME led to the recovery of a series of lipids including lysophosphatidylcholines that were decreased and a lowering of acylcarnitines that were increased in mouse plasma and liver after TAA exposure. Gene expression analysis demonstrated that the hepatoprotective effect of NME was achieved by modulation of the peroxisome proliferator-activated receptor alpha (PPAR alpha) as well as the decrease in oxidative stress. NME could not protect from TAA-induced liver injury in Ppara-null mice, suggesting that its protective effect was dependent on PPAR alpha. Myrislignan, a representative neolignan in nutmeg, showed potent protective activity against TAA-induced liver toxicity. These data demonstrate that nutmeg alleviates TAA-induced liver injury through the modulation of PPAR alpha and that the lignan compounds in nutmeg such as myrislignan partly contributed to this action.
KeywordNutmeg Hepatoprotective Activity Metabolomics Myrislignan Ppar Alpha
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Affiliation1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
2.Nanchang Univ, Coll Pharm, Nanchang 330031, Jiangxi, Peoples R China
3.Jiangxi Univ Tradit Chinese Med, Sch Pharm, Nanchang 330004, Jiangxi, Peoples R China
4.Peking Univ, Hlth Sci Ctr, Sch Pharmaceut Sci, Beijing 100191, Peoples R China
5.NCI, Lab Metab, Ctr Canc Res, NIH, Bethesda, MD 20892 USA
6.Nanjing Univ, State Key Lab Pharmaceut Biotechnol, Nanjing 210023, Jiangsu, Peoples R China
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GB/T 7714
Yang, Xiao-Nan,Liu, Xue-Mei,Fang, Jian-He,et al. PPAR alpha Mediates the Hepatoprotective Effects of Nutmeg[J]. JOURNAL OF PROTEOME RESEARCH,2018,17(5):1887-1897.
APA Yang, Xiao-Nan.,Liu, Xue-Mei.,Fang, Jian-He.,Zhu, Xu.,Yang, Xiu-Wei.,...&Li, Fei.(2018).PPAR alpha Mediates the Hepatoprotective Effects of Nutmeg.JOURNAL OF PROTEOME RESEARCH,17(5),1887-1897.
MLA Yang, Xiao-Nan,et al."PPAR alpha Mediates the Hepatoprotective Effects of Nutmeg".JOURNAL OF PROTEOME RESEARCH 17.5(2018):1887-1897.
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