Pocahemiketals A and B, two new hemiketals with unprecedented sesquiterpenoid skeletons from Pogostemon cablin
Zhu, Huan1; Zhou, Qin-Mei1; Peng, Cheng1; Chen, Ming-Hua1; Li, Xiao-Nian1; Lin, Da-Sheng1; Xiong, Liang1
2017
Source PublicationFITOTERAPIA
ISSN0367-326X
Volume120Pages:67-71
AbstractPocahemiketals A and B (1 and 2), two novel hemiketal sesquiterpenoids with unprecedented skeletons, were isolated from the essential oil of the aerial parts of Pogostemon cablin. In addition to a bicyclo[3.2.1]-carbon core, 1 and 2 possessed a hemiketal alpha,beta-unsaturated-gamma-lactone moiety. Their structures were determined by extensive spectroscopic analysis, electronic circular dichroism calculation, and single-crystal X-ray diffraction. Compound 2 exhibited significant vasorelaxant activity against phenylephrine-induced contraction of a rat aorta ring with the EC50 value of 16.32 mu M.
KeywordPogostemon Cablin Sesquiterpenoids Hemiketals Vasorelaxant Activity
DOI10.1016/j.fitote.2017.05.013
Citation statistics
Cited Times:8[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/60633
Collection植物化学与西部植物资源持续利用国家重点实验室
Affiliation1.[Zhu, Huan
2.Zhou, Qin-Mei
3.Peng, Cheng
4.Xiong, Liang] Chengdu Univ Tradit Chinese Med, Sch Pharm, Chengdu 611137, Sichuan, Peoples R China
5.[Zhu, Huan
6.Zhou, Qin-Mei
7.Peng, Cheng
8.Xiong, Liang] Chengdu Univ Tradit Chinese Med, State Key Lab Breeding Base Systemat Res Dev & Ut, Chengdu 611137, Sichuan, Peoples R China
9.[Chen, Ming-Hua] Chinese Acad Med Sci, Inst Med Biotechnol, Beijing 100050, Peoples R China
10.[Chen, Ming-Hua] Peking Union Med Coll, Beijing 100050, Peoples R China
11.[Li, Xiao-Nian] Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
12.[Lin, Da-Sheng] Chengdu Huasun Grp Co Ltd, Chengdu 610075, Sichuan, Peoples R China
Recommended Citation
GB/T 7714
Zhu, Huan,Zhou, Qin-Mei,Peng, Cheng,et al. Pocahemiketals A and B, two new hemiketals with unprecedented sesquiterpenoid skeletons from Pogostemon cablin[J]. FITOTERAPIA,2017,120:67-71.
APA Zhu, Huan.,Zhou, Qin-Mei.,Peng, Cheng.,Chen, Ming-Hua.,Li, Xiao-Nian.,...&Xiong, Liang.(2017).Pocahemiketals A and B, two new hemiketals with unprecedented sesquiterpenoid skeletons from Pogostemon cablin.FITOTERAPIA,120,67-71.
MLA Zhu, Huan,et al."Pocahemiketals A and B, two new hemiketals with unprecedented sesquiterpenoid skeletons from Pogostemon cablin".FITOTERAPIA 120(2017):67-71.
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