UFLC-MS-IT-TOF and Bioassay Guided Isolation of Flavonoids as Xanthine Oxidase Inhibitors from Diospyros dumetorum
Deng, Zhen-Tao1,2,3; Yang, Tong-Hua1,3; Huang, Xiao-Yan1,3; Chen, Xing-Long1,3; Zhang, Jian-Gang1,3; Zhang, Xue-Mei1,3; Chen, Ji-Jun1,3; Geng, Chang-An1,3
2017-11-01
发表期刊NATURAL PRODUCT COMMUNICATIONS
ISSN1934-578X
卷号12页码:1713-1715
摘要

Diospyros dumetorum is an important folk medicine for treating pulmonary abscess and inflammation. The leaves of D. dumetorum revealed xanthine oxidase (XOD) inhibitory activity. With the guidance of UFLC-MS-IT-TOF analyses combined with bioassay in vitro, 15 flavonoids were isolated from the active parts of D. dumetorum. Except for 11 (IC50> 200 mu M), all compounds showed obvious XOD inhibitory activity with IC50 values of 32.5 +/- 0.7 similar to 145.0 +/- 3.3 mu M. The preliminary structure-activity relationships study suggested that glycosylation on C-3 was unfavorable for XOD inhibitory activity; hydroxyl groups on ring B were essential for maintaining activity; the activity was closely related with the position of galloylation. This is the first recognition of the XOD inhibitory activity and active constituents of D. dumetorum, and will provide valuable information for this plant as a new resource for treating hyperuricemia and gout.

关键词Diospyros Dumetorum Uflc-ms-it-tof Bioassay-guided Isolation Xod Inhibitory Activity Flavonoids
语种英语
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文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/60611
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources West Ch, Kunming Inst Bot, Kunming 650201, Yunnan, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.Yunnan Key Lab Nat Med Chem, Kunming 650201, Yunnan, Peoples R China
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Deng, Zhen-Tao,Yang, Tong-Hua,Huang, Xiao-Yan,et al. UFLC-MS-IT-TOF and Bioassay Guided Isolation of Flavonoids as Xanthine Oxidase Inhibitors from Diospyros dumetorum[J]. NATURAL PRODUCT COMMUNICATIONS,2017,12(11):1713-1715.
APA Deng, Zhen-Tao.,Yang, Tong-Hua.,Huang, Xiao-Yan.,Chen, Xing-Long.,Zhang, Jian-Gang.,...&Geng, Chang-An.(2017).UFLC-MS-IT-TOF and Bioassay Guided Isolation of Flavonoids as Xanthine Oxidase Inhibitors from Diospyros dumetorum.NATURAL PRODUCT COMMUNICATIONS,12(11),1713-1715.
MLA Deng, Zhen-Tao,et al."UFLC-MS-IT-TOF and Bioassay Guided Isolation of Flavonoids as Xanthine Oxidase Inhibitors from Diospyros dumetorum".NATURAL PRODUCT COMMUNICATIONS 12.11(2017):1713-1715.
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