Lanostane triterpenoids from fruiting bodies of basidiomycete Stereum sp., structures and biological activities
Yao, Jian-Neng1,2; Chen, Lin3; Tang, Yang1,2; Chen, He-Ping3; Zhao, Zhen-Zhu1,2; Li, Zheng-Hui3; Feng, Tao3; Liu, Ji-Kai3
2017-12-01
Source PublicationJOURNAL OF ANTIBIOTICS
ISSN0021-8820
Volume70Issue:12Pages:1104-1111
AbstractTwelve new lanostane triterpenoids, sterenoids A-L (1-12) have been isolated from fruiting bodies of the basidiomycete Stereum sp. Compounds 1-12 are rare 14(13 -> 12) abeo-lanostane triterpenoids featuring remarkable 13R configurations that discriminate from the previously covered counterparts. Their structures and absolute configurations are assigned on the basis of in-depth one-and two-dimensional NMR spectroscopic analysis, as well as unbiased quantum chemical NMR and electronic CD calculations. All isolates are evaluated for their in vitro cytotoxicity against five human tumor cell lines. Compound 5 exhibits potent cytotoxic activities against tumor cell lines HL-60 and SMMC-7721 with IC50 values of 4.7 and 7.6 mu M, respectively.
DOI10.1038/ja.2017.122
Language英语
WOS IDWOS:000418362200004
Citation statistics
Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/60607
Collection植物化学与西部植物资源持续利用国家重点实验室
Affiliation1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming, Yunnan, Peoples R China
2.Univ Chinese Acad Sci, Beijing, Peoples R China
3.South Cent Univ Nationalities, Sch Pharmaceut Sci, Wuhan 430074, Hubei, Peoples R China
Recommended Citation
GB/T 7714
Yao, Jian-Neng,Chen, Lin,Tang, Yang,et al. Lanostane triterpenoids from fruiting bodies of basidiomycete Stereum sp., structures and biological activities[J]. JOURNAL OF ANTIBIOTICS,2017,70(12):1104-1111.
APA Yao, Jian-Neng.,Chen, Lin.,Tang, Yang.,Chen, He-Ping.,Zhao, Zhen-Zhu.,...&Liu, Ji-Kai.(2017).Lanostane triterpenoids from fruiting bodies of basidiomycete Stereum sp., structures and biological activities.JOURNAL OF ANTIBIOTICS,70(12),1104-1111.
MLA Yao, Jian-Neng,et al."Lanostane triterpenoids from fruiting bodies of basidiomycete Stereum sp., structures and biological activities".JOURNAL OF ANTIBIOTICS 70.12(2017):1104-1111.
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