| Lanostane triterpenoids from fruiting bodies of basidiomycete Stereum sp., structures and biological activities | |
| Yao, Jian-Neng1,2; Chen, Lin3; Tang, Yang1,2; Chen, He-Ping3; Zhao, Zhen-Zhu1,2; Li, Zheng-Hui3; Feng, Tao3; Liu, Ji-Kai3 | |
| 2017-12-01 | |
| Source Publication | JOURNAL OF ANTIBIOTICS
 |
| ISSN | 0021-8820 |
| Volume | 70Issue:12Pages:1104-1111 |
| Abstract | Twelve new lanostane triterpenoids, sterenoids A-L (1-12) have been isolated from fruiting bodies of the basidiomycete Stereum sp. Compounds 1-12 are rare 14(13 -> 12) abeo-lanostane triterpenoids featuring remarkable 13R configurations that discriminate from the previously covered counterparts. Their structures and absolute configurations are assigned on the basis of in-depth one-and two-dimensional NMR spectroscopic analysis, as well as unbiased quantum chemical NMR and electronic CD calculations. All isolates are evaluated for their in vitro cytotoxicity against five human tumor cell lines. Compound 5 exhibits potent cytotoxic activities against tumor cell lines HL-60 and SMMC-7721 with IC50 values of 4.7 and 7.6 mu M, respectively. |
| DOI | 10.1038/ja.2017.122 |
| Language | 英语 |
| WOS ID | WOS:000418362200004 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.kib.ac.cn/handle/151853/60607 |
| Collection | 植物化学与西部植物资源持续利用国家重点实验室 |
| Affiliation | 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming, Yunnan, Peoples R China 2.Univ Chinese Acad Sci, Beijing, Peoples R China 3.South Cent Univ Nationalities, Sch Pharmaceut Sci, Wuhan 430074, Hubei, Peoples R China |
| Recommended Citation GB/T 7714 | Yao, Jian-Neng,Chen, Lin,Tang, Yang,et al. Lanostane triterpenoids from fruiting bodies of basidiomycete Stereum sp., structures and biological activities[J]. JOURNAL OF ANTIBIOTICS,2017,70(12):1104-1111. |
| APA | Yao, Jian-Neng.,Chen, Lin.,Tang, Yang.,Chen, He-Ping.,Zhao, Zhen-Zhu.,...&Liu, Ji-Kai.(2017).Lanostane triterpenoids from fruiting bodies of basidiomycete Stereum sp., structures and biological activities.JOURNAL OF ANTIBIOTICS,70(12),1104-1111. |
| MLA | Yao, Jian-Neng,et al."Lanostane triterpenoids from fruiting bodies of basidiomycete Stereum sp., structures and biological activities".JOURNAL OF ANTIBIOTICS 70.12(2017):1104-1111. |
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