Lanostane triterpenoids from fruiting bodies of basidiomycete Stereum sp., structures and biological activities

doi:10.1038/ja.2017.122

	Lanostane triterpenoids from fruiting bodies of basidiomycete Stereum sp., structures and biological activities
	Yao, Jian-Neng 1,2; Chen, Lin 3; Tang, Yang 1,2; Chen, He-Ping 3; Zhao, Zhen-Zhu 1,2; Li, Zheng-Hui 3; Feng, Tao 3; Liu, Ji-Kai 3
	2017-12-01
发表期刊	JOURNAL OF ANTIBIOTICS
ISSN	0021-8820
卷号	70 期号:12 页码:1104-1111
摘要	Twelve new lanostane triterpenoids, sterenoids A-L (1-12) have been isolated from fruiting bodies of the basidiomycete Stereum sp. Compounds 1-12 are rare 14(13 -> 12) abeo-lanostane triterpenoids featuring remarkable 13R configurations that discriminate from the previously covered counterparts. Their structures and absolute configurations are assigned on the basis of in-depth one-and two-dimensional NMR spectroscopic analysis, as well as unbiased quantum chemical NMR and electronic CD calculations. All isolates are evaluated for their in vitro cytotoxicity against five human tumor cell lines. Compound 5 exhibits potent cytotoxic activities against tumor cell lines HL-60 and SMMC-7721 with IC50 values of 4.7 and 7.6 mu M, respectively.
DOI	10.1038/ja.2017.122
语种	英语
WOS记录号	WOS:000418362200004
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/60607
专题	植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming, Yunnan, Peoples R China 2.Univ Chinese Acad Sci, Beijing, Peoples R China 3.South Cent Univ Nationalities, Sch Pharmaceut Sci, Wuhan 430074, Hubei, Peoples R China
推荐引用方式 GB/T 7714	Yao, Jian-Neng,Chen, Lin,Tang, Yang,et al. Lanostane triterpenoids from fruiting bodies of basidiomycete Stereum sp., structures and biological activities[J]. JOURNAL OF ANTIBIOTICS,2017,70(12):1104-1111.
APA	Yao, Jian-Neng.,Chen, Lin.,Tang, Yang.,Chen, He-Ping.,Zhao, Zhen-Zhu.,...&Liu, Ji-Kai.(2017).Lanostane triterpenoids from fruiting bodies of basidiomycete Stereum sp., structures and biological activities.JOURNAL OF ANTIBIOTICS,70(12),1104-1111.
MLA	Yao, Jian-Neng,et al."Lanostane triterpenoids from fruiting bodies of basidiomycete Stereum sp., structures and biological activities".JOURNAL OF ANTIBIOTICS 70.12(2017):1104-1111.