| Design, synthesis and cytotoxicity of nitrogen-containing tanshinone derivatives | |
Li, Ming-Ming1,2,4; Xia, Fan1,2,3,4; Li, Cheng-Ji1,2,3; Xu, Gang1,2 ; Qin, Hong-Bo1,2
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| 2018-01-03 | |
| Source Publication | TETRAHEDRON LETTERS
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| ISSN | 0040-4039 |
| Volume | 59Issue:1Pages:46-48 |
| Abstract | Tanshinones were used as starting material to synthesize a small library of nitrogen heterocyclic derivatives featured with oxazole, imidazole, and pyrazine ring between C-11/C-12 by simple methods. Except for salviamine A and isosalviamine A, 22 new derivatives were synthesized. Their structures were confirmed by spectroscopic analysis. Moreover, 11 derivatives exhibited moderate cytotoxic activities against five human cancer lines in vitro. (C) 2017 Elsevier Ltd. All rights reserved. |
| Keyword | Tanshinones Heterocyclic Compounds Cytotoxicity |
| DOI | 10.1016/j.tetlet.2017.11.046 |
| Language | 英语 |
| WOS ID | WOS:000423006200010 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.kib.ac.cn/handle/151853/60591 |
| Collection | 植物化学与西部植物资源持续利用国家重点实验室 |
| Affiliation | 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 2.Yunnan Key Lab Nat Med Chem, Kunming 650201, Yunnan, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 4.Yunnan Baiyao Grp Corp Ltd, Kunming 650032, Yunnan, Peoples R China |
| Recommended Citation GB/T 7714 | Li, Ming-Ming,Xia, Fan,Li, Cheng-Ji,et al. Design, synthesis and cytotoxicity of nitrogen-containing tanshinone derivatives[J]. TETRAHEDRON LETTERS,2018,59(1):46-48. |
| APA | Li, Ming-Ming,Xia, Fan,Li, Cheng-Ji,Xu, Gang,&Qin, Hong-Bo.(2018).Design, synthesis and cytotoxicity of nitrogen-containing tanshinone derivatives.TETRAHEDRON LETTERS,59(1),46-48. |
| MLA | Li, Ming-Ming,et al."Design, synthesis and cytotoxicity of nitrogen-containing tanshinone derivatives".TETRAHEDRON LETTERS 59.1(2018):46-48. |
| Files in This Item: | Download All | |||||
| File Name/Size | DocType | Version | Access | License | ||
| li2018.pdf（299KB） | 期刊论文 | 作者接受稿 | 开放获取 | CC BY-NC-SA | View Download | |
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