Design, synthesis and cytotoxicity of nitrogen-containing tanshinone derivatives

doi:10.1016/j.tetlet.2017.11.046

	Design, synthesis and cytotoxicity of nitrogen-containing tanshinone derivatives
	Li, Ming-Ming 1,2,4; Xia, Fan 1,2,3,4; Li, Cheng-Ji 1,2,3; Xu, Gang1,2 ; Qin, Hong-Bo1,2
	2018-01-03
发表期刊	TETRAHEDRON LETTERS
ISSN	0040-4039
卷号	59 期号:1 页码:46-48
摘要	Tanshinones were used as starting material to synthesize a small library of nitrogen heterocyclic derivatives featured with oxazole, imidazole, and pyrazine ring between C-11/C-12 by simple methods. Except for salviamine A and isosalviamine A, 22 new derivatives were synthesized. Their structures were confirmed by spectroscopic analysis. Moreover, 11 derivatives exhibited moderate cytotoxic activities against five human cancer lines in vitro. (C) 2017 Elsevier Ltd. All rights reserved.
关键词	Tanshinones Heterocyclic Compounds Cytotoxicity
DOI	10.1016/j.tetlet.2017.11.046
语种	英语
WOS记录号	WOS:000423006200010
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/60591
专题	植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 2.Yunnan Key Lab Nat Med Chem, Kunming 650201, Yunnan, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 4.Yunnan Baiyao Grp Corp Ltd, Kunming 650032, Yunnan, Peoples R China
推荐引用方式 GB/T 7714	Li, Ming-Ming,Xia, Fan,Li, Cheng-Ji,et al. Design, synthesis and cytotoxicity of nitrogen-containing tanshinone derivatives[J]. TETRAHEDRON LETTERS,2018,59(1):46-48.
APA	Li, Ming-Ming,Xia, Fan,Li, Cheng-Ji,Xu, Gang,&Qin, Hong-Bo.(2018).Design, synthesis and cytotoxicity of nitrogen-containing tanshinone derivatives.TETRAHEDRON LETTERS,59(1),46-48.
MLA	Li, Ming-Ming,et al."Design, synthesis and cytotoxicity of nitrogen-containing tanshinone derivatives".TETRAHEDRON LETTERS 59.1(2018):46-48.

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