Design, synthesis and cytotoxicity of nitrogen-containing tanshinone derivatives
Li, Ming-Ming1,2,4; Xia, Fan1,2,3,4; Li, Cheng-Ji1,2,3; Xu, Gang1,2; Qin, Hong-Bo1,2
2018-01-03
发表期刊TETRAHEDRON LETTERS
ISSN0040-4039
卷号59期号:1页码:46-48
摘要Tanshinones were used as starting material to synthesize a small library of nitrogen heterocyclic derivatives featured with oxazole, imidazole, and pyrazine ring between C-11/C-12 by simple methods. Except for salviamine A and isosalviamine A, 22 new derivatives were synthesized. Their structures were confirmed by spectroscopic analysis. Moreover, 11 derivatives exhibited moderate cytotoxic activities against five human cancer lines in vitro. (C) 2017 Elsevier Ltd. All rights reserved.
关键词Tanshinones Heterocyclic Compounds Cytotoxicity
语种英语
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文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/60591
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
2.Yunnan Key Lab Nat Med Chem, Kunming 650201, Yunnan, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
4.Yunnan Baiyao Grp Corp Ltd, Kunming 650032, Yunnan, Peoples R China
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Li, Ming-Ming,Xia, Fan,Li, Cheng-Ji,et al. Design, synthesis and cytotoxicity of nitrogen-containing tanshinone derivatives[J]. TETRAHEDRON LETTERS,2018,59(1):46-48.
APA Li, Ming-Ming,Xia, Fan,Li, Cheng-Ji,Xu, Gang,&Qin, Hong-Bo.(2018).Design, synthesis and cytotoxicity of nitrogen-containing tanshinone derivatives.TETRAHEDRON LETTERS,59(1),46-48.
MLA Li, Ming-Ming,et al."Design, synthesis and cytotoxicity of nitrogen-containing tanshinone derivatives".TETRAHEDRON LETTERS 59.1(2018):46-48.
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