Alkaloids as Cyclooxygenase Inhibitors in Anticancer Drug Discovery

doi:10.2174/1389203718666170106103031

	Alkaloids as Cyclooxygenase Inhibitors in Anticancer Drug Discovery
	Hashmi, Muhammad Ali 1; Khan, Afsar 1; Farooq, Umar 1; Khan, Sehroon 2
	2018
发表期刊	CURRENT PROTEIN & PEPTIDE SCIENCE
ISSN	1389-2037
卷号	19 期号:3 页码:292-301
摘要	Cancer is the leading cause of death worldwide and anticancer drug discovery is a very hot area of research at present. There are various factors which control and affect cancer, out of which enzymes like cyclooxygenase-2 (COX-2) play a vital role in the growth of tumor cells. Inhibition of this enzyme is a very useful target for the prevention of various types of cancers. Alkaloids are a diverse group of naturally occurring compounds which have shown great COX-2 inhibitory activity both in vitro and in vivo. In this mini-review, we have discussed different alkaloids with COX-2 inhibitory activities and anticancer potential which may act as leads in modern anticancer drug discovery. Different classes of alkaloids including isoquinoline alkaloids, indole alkaloids, piperidine alkaloids, quinazoline alkaloids, and various miscellaneous alkaloids obtained from natural sources have been discussed in detail in this review.
关键词	Anticancer Cyclooxygenase Cox-2 Alkaloids Enzyme Inhibition Anti-inflammatory Anti-tumor
DOI	10.2174/1389203718666170106103031
语种	英语
WOS记录号	WOS:000419465300004
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/60584
专题	植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.COMSATS Inst Informat Technol, Dept Chem, Abbottabad 22060, Pakistan 2.Chinese Acad Sci, Kunming Inst Bot, Key Lab Econ Plants & Biotechnol, Kunming 560201, Yunnan, Peoples R China
推荐引用方式 GB/T 7714	Hashmi, Muhammad Ali,Khan, Afsar,Farooq, Umar,et al. Alkaloids as Cyclooxygenase Inhibitors in Anticancer Drug Discovery[J]. CURRENT PROTEIN & PEPTIDE SCIENCE,2018,19(3):292-301.
APA	Hashmi, Muhammad Ali,Khan, Afsar,Farooq, Umar,&Khan, Sehroon.(2018).Alkaloids as Cyclooxygenase Inhibitors in Anticancer Drug Discovery.CURRENT PROTEIN & PEPTIDE SCIENCE,19(3),292-301.
MLA	Hashmi, Muhammad Ali,et al."Alkaloids as Cyclooxygenase Inhibitors in Anticancer Drug Discovery".CURRENT PROTEIN & PEPTIDE SCIENCE 19.3(2018):292-301.