Alkaloids as Cyclooxygenase Inhibitors in Anticancer Drug Discovery
Hashmi, Muhammad Ali1; Khan, Afsar1; Farooq, Umar1; Khan, Sehroon2
2018
发表期刊CURRENT PROTEIN & PEPTIDE SCIENCE
ISSN1389-2037
卷号19期号:3页码:292-301
摘要Cancer is the leading cause of death worldwide and anticancer drug discovery is a very hot area of research at present. There are various factors which control and affect cancer, out of which enzymes like cyclooxygenase-2 (COX-2) play a vital role in the growth of tumor cells. Inhibition of this enzyme is a very useful target for the prevention of various types of cancers. Alkaloids are a diverse group of naturally occurring compounds which have shown great COX-2 inhibitory activity both in vitro and in vivo. In this mini-review, we have discussed different alkaloids with COX-2 inhibitory activities and anticancer potential which may act as leads in modern anticancer drug discovery. Different classes of alkaloids including isoquinoline alkaloids, indole alkaloids, piperidine alkaloids, quinazoline alkaloids, and various miscellaneous alkaloids obtained from natural sources have been discussed in detail in this review.
关键词Anticancer Cyclooxygenase Cox-2 Alkaloids Enzyme Inhibition Anti-inflammatory Anti-tumor
语种英语
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文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/60584
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.COMSATS Inst Informat Technol, Dept Chem, Abbottabad 22060, Pakistan
2.Chinese Acad Sci, Kunming Inst Bot, Key Lab Econ Plants & Biotechnol, Kunming 560201, Yunnan, Peoples R China
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Hashmi, Muhammad Ali,Khan, Afsar,Farooq, Umar,et al. Alkaloids as Cyclooxygenase Inhibitors in Anticancer Drug Discovery[J]. CURRENT PROTEIN & PEPTIDE SCIENCE,2018,19(3):292-301.
APA Hashmi, Muhammad Ali,Khan, Afsar,Farooq, Umar,&Khan, Sehroon.(2018).Alkaloids as Cyclooxygenase Inhibitors in Anticancer Drug Discovery.CURRENT PROTEIN & PEPTIDE SCIENCE,19(3),292-301.
MLA Hashmi, Muhammad Ali,et al."Alkaloids as Cyclooxygenase Inhibitors in Anticancer Drug Discovery".CURRENT PROTEIN & PEPTIDE SCIENCE 19.3(2018):292-301.
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