Chromanopyrones and a flavone from Hypericum monogynum
Zeng, Yan-Rong1,2,3; Wang, Li-Ping1,2,3; Hu, Zhan-Xing1,3; Yi, Ping1,2,3; Yang, Wan-Xia1,2,3; Gu, Wei1,2,3; Huang, Lie-Jun1,2,3; Yuan, Chun-Mao1,2,3; Hao, Xiao-Jiang1,2,3,4
2018-03-01
Source PublicationFITOTERAPIA
ISSN0367-326X
Volume125Pages:59-64
AbstractSix new compounds, including three pyrone derivatives (2-4), one new flavone (5), and two new naturally-occurring compounds (1 and 6), together with 16 known compounds were isolated from the leaves and twigs of Hypericum monogynum. In addition, compounds 2-4 are racemates. Their structures and absolute configurations were determined on the basis of extensive analysis of spectroscopic data and ECD calculation. All compounds were evaluated for the inhibitory effects on alpha-glucosidase, compounds 1, 5, and 7 showed moderate inhibitory activities with IC50 values of 161.46, 257.78, and 11.54 mu g/ml, respectively. Compound 8 exhibited weak antioxidant activity with IC50 value of 12.55 mu g/ml.
KeywordHypericum Monogynum Pyrone Derivatives Inhibitory Effects On Alpha-glucosidase Anti-oxidant Activity
DOI10.1016/j.fitote.2017.12.013
Language英语
WOS IDWOS:000425560500010
Citation statistics
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/60549
Collection植物化学与西部植物资源持续利用国家重点实验室
Affiliation1.Guizhou Med Univ, State Key Lab Funct & Applicat Med Plants, Guiyang 550014, Guizhou, Peoples R China
2.Guizhou Med Univ, Sch Pharmacuet Sci, Guiyang 550025, Guizhou, Peoples R China
3.Chinese Acad Sci, Key Lab Chem Nat Prod Guizhou Prov, Guiyang 550014, Guizhou, Peoples R China
4.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
Recommended Citation
GB/T 7714
Zeng, Yan-Rong,Wang, Li-Ping,Hu, Zhan-Xing,et al. Chromanopyrones and a flavone from Hypericum monogynum[J]. FITOTERAPIA,2018,125:59-64.
APA Zeng, Yan-Rong.,Wang, Li-Ping.,Hu, Zhan-Xing.,Yi, Ping.,Yang, Wan-Xia.,...&Hao, Xiao-Jiang.(2018).Chromanopyrones and a flavone from Hypericum monogynum.FITOTERAPIA,125,59-64.
MLA Zeng, Yan-Rong,et al."Chromanopyrones and a flavone from Hypericum monogynum".FITOTERAPIA 125(2018):59-64.
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